ArticlePloS one2013
Genome-wide association study reveals constant and specific loci for hematological traits at three time stages in a White Duroc × Erhualian F2 resource population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association analyses for meat quality traits in Chinese Erhualian pigs and a Western Duroc × (Landrace × Yorkshire) commercial population.Genetics, selection, evolution : GSE · 2015Pooled it
- Genome-Wide Association Studies for 24 Hematological Traits in Production Pigs Before and After Weaning.Animal genetics · 2026Article
- Genetic factors for hematological traits in pigs.Animal genetics · 2025Review
- Parental Phasing Study Identified Lineage-Specific Variants Associated with Gene Expression and Epigenetic Modifications in European-Chinese Hybrid Pigs.Animals : an open access journal from MDPI · 2025Article
- Genetic dissection and genomic prediction for pork cuts and carcass morphology traits in pig.Journal of animal science and biotechnology · 2023Article
- Multivariate genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2023Article
- An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population.Science China. Life sciences · 2022Article
- Genome-Wide Association Study on the Hematological Phenotypic Characteristics of the Han Population from Northwest China.Pharmacogenomics and personalized medicine · 2022Article
- Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis.Journal of animal science and biotechnology · 2021Article
- Genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2021Article
- Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse.Frontiers in immunology · 2021Article
- Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs.Scientific reports · 2020Article
- Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle.BMC genetics · 2020Article
- Article
- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- New world goat populations are a genetically diverse reservoir for future use.Scientific reports · 2019Article
- Imputation-Based Whole-Genome Sequence Association Study Reveals Constant and Novel Loci for Hematological Traits in a Large-Scale Swine FFrontiers in genetics · 2018Article
- Single- and Bayesian Multi-Marker Genome-Wide Association for Haematological Parameters in Pigs.PloS one · 2016Article
- Multi-breed genome-wide association study reveals novel loci associated with the weight of internal organs.Genetics, selection, evolution : GSE · 2015Article
- Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens.BMC genomics · 2015Article
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Authors and funding
8 authors.
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Abstract
Hematological traits are important indicators of immune function and have been commonly examined as biomarkers of disease and disease severity in humans. Pig is an ideal biomedical model for human diseases due to its high degree of similarity with human physiological characteristics. Here, we conducted genome-wide association studies (GWAS) for 18 hematological traits at three growth stages (days 18, 46 and 240) in a White Duroc × Erhualian F2 intercross. In total, we identified 38 genome-wide significant regions containing 185 genome-wide significant SNPs by single-marker GWAS or LONG-GWAS. The significant regions are distributed on pig chromosomes (SSC) 1, 4, 5, 7, 8, 10, 11, 12, 13, 17 and 18, and most of significant SNPs reside on SSC7 and SSC8. Of the 38 significant regions, 7 show constant effects on hematological traits across the whole life stages, and 6 regions have time-specific effects on the measured traits at early or late stages. The most prominent locus is the genomic region between 32.36 and 84.49 Mb on SSC8 that is associated with multiple erythroid traits. The KIT gene in this region appears to be a promising candidate gene. The findings improve our understanding of the genetic architecture of hematological traits in pigs. Further investigations are warranted to characterize the responsible gene(s) and causal variant(s) especially for the major loci on SSC7 and SSC8.
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