ArticlePloS one2013
Impact of variation at the FTO locus on milk fat yield in Holstein dairy cattle.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.Animals : an open access journal from MDPI · 2023Article
- Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.Animals : an open access journal from MDPI · 2023Review
- Candidate Genes and Their Expressions Involved in the Regulation of Milk and Meat Production and Quality in Goats (Animals : an open access journal from MDPI · 2022Review
- Assessing the genetic background and genomic relatedness of red cattle populations originating from Northern Europe.Genetics, selection, evolution : GSE · 2021Article
- Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review.Animals : an open access journal from MDPI · 2021Review
- Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity.The Journal of clinical endocrinology and metabolism · 2021Article
- Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other TwoFrontiers in genetics · 2021Article
- Genomic Loci Affecting Milk Production in German Black Pied Cattle (DSN).Frontiers in genetics · 2021Article
- Review
- Goat Genomic Resources: The Search for Genes Associated with Its Economic Traits.International journal of genomics · 2020Review
- Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle.Veterinary world · 2019Article
- Genome-wide association study of endo-parasite phenotypes using imputed whole-genome sequence data in dairy and beef cattle.Genetics, selection, evolution : GSE · 2019Article
- Milk's Role as an Epigenetic Regulator in Health and Disease.Diseases (Basel, Switzerland) · 2017Review
- High density genome wide genotyping-by-sequencing and association identifies common and low frequency SNPs, and novel candidate genes influencing cow milk traits.Scientific reports · 2016Article
- Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.Journal of translational medicine · 2015Review
- Go with the flow-biology and genetics of the lactation cycle.Frontiers in genetics · 2015Review
- Single nucleotide polymorphism and haplotype effects associated with somatic cell score in German Holstein cattle.Genetics, selection, evolution : GSE · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores the biological role of the Fat Mass and Obesity associated (FTO) gene locus on milk composition in German Holstein cattle. Since FTO controls energy homeostasis and expenditure and the FTO locus has repeatedly shown association with obesity in human studies, we tested FTO as a candidate gene in particular for milk fat yield, which represents a high amount of energy secreted during lactation. The study was performed on 2,402 bulls and 860 cows where dense milk composition data were available. Genetic information was taken from a 2 Mb region around FTO. Five SNPs and two haplotype blocks in a 725 kb region covering FTO and the neighboring genes RPGRIP1L, U6ATAC, and 5 S rRNA were associated with milk fat yield and also affected protein yield in the same direction. Interestingly, higher frequency SNP alleles and haplotypes within the FTO gene increased milk fat and protein yields by up to 2.8 and 2.2 kg per lactation, respectively, while the most frequent haplotype in the upstream block covering exon 1 of FTO to exon 15 of RPGRIP1L had opposite effects with lower fat and milk yield. Both haplotype blocks were also significant in cows. The loci accounted for about 1% of the corresponding trait variance in the population. The association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein yield. The pleiotropic effects suggest a biological function on the usage of energy resources and the control of energy balance rather than directly affecting fat and protein synthesis. The identified effect of the obesity gene locus on milk energy content suggests an impact on infant nutrition by breast feeding in humans.
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