ArticlePloS one2013
Fitness of transgenic mosquito Aedes aegypti males carrying a dominant lethal genetic system.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Engineering Protein Stability with Small Molecules: A Review of the ecDHFR Destabilizing Domain System.ACS chemical biology · 2026Review
- Recombinant venom proteins in insect seminal fluid reduce female lifespan.Nature communications · 2025Article
- Review
- Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti.Scientific reports · 2023Article
- Insect allies-Assessment of a viral approach to plant genome editing.Integrated environmental assessment and management · 2022Review
- Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes.PLoS neglected tropical diseases · 2022Article
- Increased biting rate and decreased Wolbachia density in irradiated Aedes mosquitoes.Parasites & vectors · 2022Article
- The impact of transgenesis on mosquito fitness: A review.Frontiers in insect science · 2022Review
- Effect of cage size onHeliyon · 2021Article
- Mating Competitiveness of Transgenic Aedes aegypti (Diptera: Culicidae) Males Against Wild-Type Males Reared Under Simulated Field Conditions.Journal of medical entomology · 2020Article
- Impact of pyriproxyfen on virus behavior: implications for pesticide-induced virulence and mechanism of transmission.Virology journal · 2020Article
- Experimental population modification of the malaria vector mosquito, Anopheles stephensi.PLoS genetics · 2019Article
- Reply to 'Concerns about the feasibility of using "precision guided sterile males" to control insects'.Nature communications · 2019Article
- Too "sexy" for the field? Paired measures of laboratory and semi-field performance highlight variability in the apparent mating fitness of Aedes aegypti transgenic strains.Parasites & vectors · 2019Article
- A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control.Acta tropica · 2018Article
- Controlling vector-borne diseases by releasing modified mosquitoes.Nature reviews. Microbiology · 2018Review
- Combining Wolbachia-induced sterility and virus protection to fight Aedes albopictus-borne viruses.PLoS neglected tropical diseases · 2018Article
- The Effect of Larval Diet on Adult Survival, Swarming Activity and Copulation Success in Male Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2018Article
- Mosquito pornoscopy: Observation and interruption of Aedes aegypti copulation to determine female polyandric event and mixed progeny.PloS one · 2018Article
- Transcriptional effects of a positive feedback circuit in Drosophila melanogaster.BMC genomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OX513A is a transgenic strain of Aedes aegypti engineered to carry a dominant, non-sex-specific, late-acting lethal genetic system that is repressed in the presence of tetracycline. It was designed for use in a sterile-insect (SIT) pest control system called RIDL® (Release of Insects carrying a Dominant Lethal gene) by which transgenic males are released in the field to mate with wild females; in the absence of tetracycline, the progeny from such matings will not survive. We investigated the mating fitness of OX513A in the laboratory. Male OX513A were as effective as Rockefeller (ROCK) males at inducing refractoriness to further mating in wild type females and there was no reduction in their ability to inseminate multiple females. They had a lower mating success but yielded more progeny than the wild-type comparator strain (ROCK) when one male of each strain was caged with a ROCK female. Mating success and fertility of groups of 10 males-with different ratios of RIDL to ROCK-competing for five ROCK females was similar, but the median longevity of RIDL males was somewhat (18%) lower. We conclude that the fitness under laboratory conditions of OX513A males carrying a tetracycline repressible lethal gene is comparable to that of males of the wild-type comparator strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.