ArticleEvidence-based complementary and alternative medicine : eCAM2013
Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Effects and mechanisms of probiotics supplement on hypertension.Journal of hypertension · 2026Review
- Regulatory effect of gut microbes on blood pressure.Animal models and experimental medicine · 2022Review
- Antihypertensive Activity of Milk Fermented by Lactiplantibacillus plantarum SR37-3 and SR61-2 in L-NAME-Induced Hypertensive RatsFoods (Basel, Switzerland) · 2022Article
- Article
- Review
- Effect of probiotic foods and supplements on blood pressure: a systematic review of meta-analyses studies of controlled trials.Journal of diabetes and metabolic disorders · 2020Review
- Fermentation of Cauliflower and White Beans with Lactobacillus plantarum - Impact on Levels of Riboflavin, Folate, Vitamin BPlant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Impact of Gut Microbiota Composition on Onset and Progression of Chronic Non-Communicable Diseases.Nutrients · 2019Review
- Hypertensive Rats Treated Chronically With NFrontiers in pharmacology · 2019Article
- Probiotics as Beneficial Dietary Supplements to Prevent and Treat Cardiovascular Diseases: Uncovering Their Impact on Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- Antihypertensive Effects of Probiotics.Current hypertension reports · 2017Review
- The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?Frontiers in pediatrics · 2017Review
- Brain-Gut-Bone Marrow Axis: Implications for Hypertension and Related Therapeutics.Circulation research · 2016Review
- Gut dysbiosis is linked to hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats.BMC genomics · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host. However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome. The N(G)-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement of Lactobacillus plantarum HEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermentation. The experimental diets did not lower the blood pressure after 4 weeks. However, the fermented blueberries together with live L. plantarum showed protective effect on liver cells indicated by suppressed increase of serum alanine aminotransferase (ALAT) levels. The diversity of the caecal microbiota was neither affected by L-NAME nor the experimental diets. However, inhibition of the nitric oxide synthesis by L-NAME exerted a selection pressure that led to a shift in the bacterial composition. The mixture of fermented blueberries with the bacterial strain altered the caecal microbiota in different direction compared to L-NAME, while the three phenolic compounds together with the bacteria eliminated the selection pressure from the L-NAME.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.