ArticleEvidence-based complementary and alternative medicine : eCAM2013
Differences in metabolites of different tongue coatings in patients with chronic hepatitis B.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Metabolomic Profiling of Tongue Coating Reveals Potential Molecular Features Linked to Type 2 Diabetes Progression.International journal of molecular sciences · 2026Article
- Tongue-coating microbiome as a predictor of solid tumors: an updated scoping review of clinical studies.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Distinct microbiome of tongue coating and gut in type 2 diabetes with yellow tongue coating.Heliyon · 2024Article
- Application of tongue image characteristics and oral-gut microbiota in predicting pre-diabetes and type 2 diabetes with machine learning.Frontiers in cellular and infection microbiology · 2024Article
- Metabolomics in viral hepatitis: advances and review.Frontiers in cellular and infection microbiology · 2023Review
- Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis.Chinese journal of integrative medicine · 2022Article
- Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Intra-Rater and Inter-Rater Reliability of Tongue Coating Diagnosis in Traditional Chinese Medicine Using Smartphones: Quasi-Delphi Study.JMIR mHealth and uHealth · 2020Article
- Chronic hepatitis B: dynamic change in Traditional Chinese Medicine syndrome by dynamic network biomarkers.Chinese medicine · 2019Article
- Serum starvation-induces down-regulation of Bcl-2/Bax confers apoptosis in tongue coating-related cells in vitro.Molecular medicine reports · 2018Article
- Urinary Metabolomic Profiling in Chronic Hepatitis B Viral Infection Using Gas Chromatography/Mass SpectrometryAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Classification of Gan Dan Shi Re Pattern and Gan Shen Yin Xu Pattern in Patients with Hepatitis B Cirrhosis Using Metabonomics.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Evaluation of the Bacterial Diversity in the Human Tongue Coating Based on Genus-Specific Primers for 16S rRNA Sequencing.BioMed research international · 2017Article
- The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- ROC-Boosting: A Feature Selection Method for Health Identification Using Tongue Image.Computational and mathematical methods in medicine · 2015Article
- Study of ZHENG differentiation in hepatitis B-caused cirrhosis: a transcriptional profiling analysis.BMC complementary and alternative medicine · 2014Article
- Color distribution differences in the tongue in sleep disorder.Evidence-based complementary and alternative medicine : eCAM · 2014Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tongue coating is one of the important foundations of tongue diagnosis in traditional Chinese medicine (TCM) and plays an important role in reflecting the occurrence, development, and prognosis of the disease. However, its material basis is still poorly understood. In this study, a urinary metabonomic method based on gas chromatography coupled to mass spectrometry (GC/MS) was developed. The distinct clustering in metabolic profile was observed from Group A (thick yellow coating in patients with chronic hepatitis B), Group B (thick white coating in patients with chronic hepatitis B), and Group C (thin white coating with healthy humans) using orthogonal projections to latent structures (OPLS). Based on the variable of importance in the project (VIP) values, some significantly changed metabolites have been identified. These changes were related to the disturbance in energy metabolism, amino acid metabolism, nucleotide metabolism, and gut microflora, which were helpful to understand the material basis leading to the formation of tongue coating. This study demonstrated that tongue coating may have an objective material basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.