ArticleVascular health and risk management2013
Red blood cell count as an indicator of microvascular complications in Chinese patients with type 2 diabetes mellitus.
Article in Vascular health and risk management, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Key biomarkers in type 2 diabetes patients: A systematic review.Diabetes, obesity & metabolism · 2025Pooled it
- Association between peripheral blood biomarkers and diabetic macular edema.Acta diabetologica · 2026Article
- Cervical spinal cord enlargement and systemic inflammation in diabetic peripheral neuropathy: a cross-sectional MRI study.Irish journal of medical science · 2026Article
- A nomogram prediction model incorporating noninvasive lens AGEs and conventional biochemical indicators for assessing and predicting diabetic kidney disease.Scientific reports · 2026Article
- Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study.International journal of general medicine · 2026Article
- Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus.Investigative ophthalmology & visual science · 2025Article
- Red blood cell count and its inverse association with diabetic retinopathy: Exploratory development of a risk assessment model in a retrospective cohort.Frontiers in endocrinology · 2025Article
- Red blood cell count and cystatin C as the specific biomarkers for diabetic retinopathy from diabetes mellitus: a case-control study.Scientific reports · 2024Article
- Association between hematological indices and blood glucose level among patients with type 2 diabetes.Irish journal of medical science · 2024Article
- Prediction of type 2 diabetes mellitus using hematological factors based on machine learning approaches: a cohort study analysis.Scientific reports · 2023Article
- Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Lipid and Haematologic Profiling of Regular Blood Donors Revealed Health Benefits.Journal of blood medicine · 2022Article
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- The Relationship between Erythrocytes and Diabetes Mellitus.Journal of diabetes research · 2021Review
- Article
- [Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- The Impact of Glycemic Status and Metformin Administration on Red Blood Cell Indices and Oxidative Stress in Type 2 Diabetic Patients.The Malaysian journal of medical sciences : MJMS · 2019Article
- The effect of consumption of garlic tablet on proteins oxidation biomarkers in postmenopausal osteoporotic women: A randomized clinical trial.Electronic physician · 2017Article
- Association of hematological indices with prediabetes: A cross-sectional study.Electronic physician · 2017Article
- Increased 8-hydroxy-2'-deoxyguanosine in leukocyte DNA from patients with type 2 diabetes and microangiopathy.The Journal of international medical research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRheological disorders of red blood cells (RBC) and decreased RBC deformability have been involved in the development of diabetic microangiopathy. However, few studies have evaluated the association of RBC count with microvascular complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association of RBC count with microvascular complications in patients with T2DM.
methodsThis study involved 369 patients with T2DM: 243 with one or more microvascular complications and 126 without microvascular complications. Anticoagulated blood was collected and analyzed in an automated blood cell counter. The presence of risk factors for microvascular complications was determined.
resultsThe proportion of patients with microvascular complications increased as the RBC count decreased (P < 0.001). After adjustment for known risk factors for microvascular complications by logistic regression analysis, lower quartiles of RBC count were associated with a higher risk of microvascular complications compared with the reference group composed of the highest quartile (first quartile, odds ratio 4.98, 95% confidence interval 1.54-6.19, P = 0.008; second quartile, odds ratio 3.21, 95% confidence interval 1.17-5.28, P = 0.024).
conclusionA decreased RBC count is associated with microvascular complications in Chinese patients with T2DM. The RBC count is a potential marker to improve further the ability to identify diabetic patients at high risk of microvascular complications.
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