ArticleInternational journal of nanomedicine2013
Enhancing the bioactivity of Poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature-A Systematic Review.BioMed research international · 2017Pooled it
- The Sr-HA-loaded PLGA cage structure combines cells to construct a bone tissue repair unit.Regenerative biomaterials · 2026Article
- Bioaugmented osteosynthesis: precise monitoring and intervention of the bone healing microenvironment.Bone research · 2025Article
- Surface modification of polyetheretherketone for boosted osseointegration: A review.Biomaterials translational · 2025Review
- Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.Drug design, development and therapy · 2024Review
- Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds.Frontiers in bioengineering and biotechnology · 2023Review
- When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Journal of functional biomaterials · 2022Article
- Decellularized Human Umbilical Tissue-Derived Hydrogels Promote Proliferation and Chondrogenic Differentiation of Mesenchymal Stem Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022Review
- Poly(lactic-Bioactive materials · 2021Review
- Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors.Communications biology · 2021Article
- Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite.ACS omega · 2019Article
- The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro.Polymers · 2019Article
- Elaboration and Biocompatibility of an Eggshell-Derived Hydroxyapatite Material Modified with Si/PLGA for Bone Regeneration in Dentistry.International journal of dentistry · 2019Article
- Enhanced osteoinduction of electrospun scaffolds with assemblies of hematite nanoparticles as a bioactive interface.International journal of nanomedicine · 2019Article
- Nano-Hydroxyapatite Coating Promotes Porous Calcium Phosphate Ceramic-Induced Osteogenesis Via BMP/Smad Signaling Pathway.International journal of nanomedicine · 2019Article
- Drug-Loaded Biomimetic Ceramics for Tissue Engineering.Pharmaceutics · 2018Review
- 3D bioactive composite scaffolds for bone tissue engineering.Bioactive materials · 2018Review
- Journey into Bone Models: A Review.Genes · 2018Review
- In Vitro Comparative Study of Oxygen Plasma Treated Poly(Lactic⁻Co⁻Glycolic) (PLGA) Membranes and Supported Nanostructured Oxides for Guided Bone Regeneration Processes.Materials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePoly(lactic-co-glycolic acid) (PLGA) is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA) was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keeping the polyester skeleton of the scaffolds.
methodsPLGA porous scaffolds were prepared and surface modification was carried out by incubation in modified simulated body fluids. The nHA coated PLGA scaffolds were compared to the virgin PLGA scaffolds both in vitro and in vivo. Viability and proliferation rate of bone marrow stromal cells of rabbits were examined. The constructs of scaffolds and autogenous bone marrow stromal cells were implanted into the segmental bone defect in the rabbit model, and the bone regeneration effects were observed.
resultsIn contrast to the relative smooth pore surface of the virgin PLGA scaffold, a biomimetic hierarchical nanostructure was found on the surface of the interior pores of the nHA coated PLGA scaffolds by scanning electron microscopy. Both the viability and proliferation rate of the cells seeded in nHA coated PLGA scaffolds were higher than those in PLGA scaffolds. For bone defect repairing, the radius defects had, after 12 weeks implantation of nHA coated PLGA scaffolds, completely recuperated with significantly better bone formation than in the group of virgin PLGA scaffolds, as shown by X-ray, Micro-computerized tomography and histological examinations.
conclusionnHA coating on the interior pore surfaces can significantly improve the bioactivity of PLGA porous scaffolds.
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