ArticleMediators of inflammation2013
Cytokines and chemokines as biomarkers of community-acquired bacterial infection.
Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
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- Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections.Veterinary medicine and science · 2024Article
- Cancer cachexia: biomarkers and the influence of age.Molecular oncology · 2024Review
- Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study.Frontiers in immunology · 2023Article
- Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia.Frontiers in medicine · 2023Article
- Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.Frontiers in pediatrics · 2023Article
- Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing.Science advances · 2022Article
- Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity.Frontiers in immunology · 2022Article
- A cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patients.PloS one · 2022Article
- Interleukin 6 as a marker of severe bacterial infection in children with sickle cell disease and fever: a case-control study.BMC infectious diseases · 2021Article
- Potential of Point-of-Care and At-Home Assessment of Immune Status via Rapid Cytokine Detection and Questionnaire-Based Anamnesis.Sensors (Basel, Switzerland) · 2021Article
- Electrochemical Biosensors for Cytokine Profiling: Recent Advancements and Possibilities in the Near Future.Biosensors · 2021Review
- Different Modulatory Effects of Four Methicillin-ResistantBiomolecules · 2021Article
- Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: "IFN-High," "NE-High," and "Mixed".Mediators of inflammation · 2021Article
- UvrY is required for the full virulence ofVirulence · 2020Article
- Profile of common inflammatory markers in treatment-naïve patients with systemic rheumatic diseases.Clinical rheumatology · 2020Article
- Plasma lipid profiles discriminate bacterial from viral infection in febrile children.Scientific reports · 2019Article
- Small intestinal transcriptome analysis revealed changes of genes involved in nutrition metabolism and immune responses in growth retardation piglets1.Journal of animal science · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF- α , INF- γ , MIP-1 β , and MCP-1. Bacterial etiology of infection was associated with significantly (P < 0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF- α in comparison to levels observed in the sera of patients with viral infections. In the patients with bacterial infections, IL-1Ra and IL-8 demonstrated positive correlation with C-reactive protein, whereas, IL-1Ra, TNF- α , and MCP-1 correlated with procalcitonin. Furthermore, elevated levels of IL-1Ra, IL-6, and TNF- α decreased within 3 days of antibiotic therapy to levels observed in control subjects. The results show IL-1Ra as a potential useful biomarker of community-acquired bacterial infection.
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