ArticleProceedings of the National Academy of Sciences of the United States of America2013
Impairing existing declarative memory in humans by disrupting reconsolidation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 131 citations in OpenAlex.
- Trial
- Effects of Prereactivation Propranolol on Cocaine Craving Elicited by Imagery Script/Cue Sets in Opioid-dependent Polydrug Users: A Randomized Study.Journal of addiction medicineTrial
- Memory updating and the structure of event representations.Trends in cognitive sciences · 2025Review
- Timing of pre-retrieval warnings matters in reducing memory errors in a repeated testing misinformation study.Scientific reports · 2025Article
- Proteomic-Based Studies on Memory Formation in Normal and Neurodegenerative Disease-Affected Brains.Advances in experimental medicine and biology · 2024Review
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Behavioural reconsolidation interference not observed in a within-subjects design.NPJ science of learning · 2022Article
- Relearning can eliminate the effect of retrieval-induced forgetting.Psychological research · 2022Article
- Sleep enhances reconsolidation-based strengthening of visuospatial memories.Scientific reports · 2022Article
- Is Reconsolidation a General Property of Memory?Frontiers in human neuroscience · 2021Review
- Post-retrieval Distortions of Self-Referential Negative Memory: Valence Consistency Enhances Gist-Directed False, While Non-negative Interference Generates More Intrusive Updates.Frontiers in psychology · 2021Article
- How prior testing impacts misinformation processing: A dual-task approach.Memory & cognition · 2020Article
- Intrusive memories and voluntary memory of a trauma film: Differential effects of a cognitive interference task after encoding.Journal of experimental psychology. General · 2019Article
- Pavlov's Pain: the Effect of Classical Conditioning on Pain Perception and its Clinical Implications.Current pain and headache reports · 2019Review
- Susceptibility of consolidated procedural memory to interference is independent of its active task-based retrieval.PloS one · 2019Article
- Knowledge acquisition is governed by striatal prediction errors.Nature communications · 2018Article
- Re-stepping into the same river: competition problem rather than a reconsolidation failure in an established motor skill.Scientific reports · 2017Article
- Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments.Neurobiology of learning and memory · 2017Review
- The computational nature of memory modification.eLife · 2017Article
- Flexible retrieval: When true inferences produce false memories.Journal of experimental psychology. Learning, memory, and cognition · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past decade, a large body of research has shown that memory traces can become labile upon retrieval and must be restabilized. Critically, interrupting this reconsolidation process can abolish a previously stable memory. Although a large number of studies have demonstrated this reconsolidation associated amnesia in nonhuman animals, the evidence for its occurrence in humans is far less compelling, especially with regard to declarative memory. In fact, reactivating a declarative memory often makes it more robust and less susceptible to subsequent disruptions. Here we show that existing declarative memories can be selectively impaired by using a noninvasive retrieval-relearning technique. In six experiments, we show that this reconsolidation-associated amnesia can be achieved 48 h after formation of the original memory, but only if relearning occurred soon after retrieval. Furthermore, the amnesic effect persists for at least 24 h, cannot be attributed solely to source confusion and is attainable only when relearning targets specific existing memories for impairment. These results demonstrate that human declarative memory can be selectively rewritten during reconsolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.