ArticleProceedings of the National Academy of Sciences of the United States of America2013
Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04094350 (Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia: Study Protocol for a Pragmatic Cluster Randomized Controlled Trial
Who cites it
20 citing papers in PubMed.
- Trial
- Evaluating COVID-19 vaccine allocation policies using Bayesian m-top exploration.Scientific reports · 2026Article
- Impact of active case-finding for tuberculosis on case-notifications in Blantyre, Malawi: A community-based cluster-randomised trial (SCALE).PLOS global public health · 2023Article
- Mathematical modelling of the progression of active tuberculosis: Insights from fluorography data.Infectious Disease Modelling · 2022Article
- Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making.Epidemics · 2022Article
- Adaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic.Medical decision making : an international journal of the Society for Medical Decision Making · 2021Article
- The DIOS framework for optimizing infectious disease surveillance: Numerical methods for simulation and multi-objective optimization of surveillance network architectures.PLoS computational biology · 2020Article
- Cost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: a model-based analysis.The Lancet. Global health · 2020Article
- Mobilising community networks for early identification of tuberculosis and treatment initiation in Cambodia: an evaluation of a seed-and-recruit model.ERJ open research · 2020Article
- Delayed diagnosis and treatment of pulmonary tuberculosis in high-burden countries: a systematic review protocol.BMJ open · 2019Article
- Yield of systematic household contact investigation for tuberculosis in a high-burden metropolitan district of South Africa.BMC public health · 2019Article
- Estimating the Impact of Tuberculosis Case Detection in Constrained Health Systems: An Example of Case-Finding in South Africa.American journal of epidemiology · 2019Article
- Modeling tuberculosis dynamics with the presence of hyper-susceptible individuals for Ho Chi Minh City from 1996 to 2015.BMC infectious diseases · 2018Article
- Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study.The Lancet. Global health · 2018Article
- Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa.PloS one · 2016Article
- Permutations of time and place in tuberculosis.The Lancet. Infectious diseases · 2015Review
- Effectiveness of contact investigations for tuberculosis control in Arkansas.Journal of theoretical biology · 2015Article
- Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa.PloS one · 2015Article
- How much is tuberculosis screening worth? Estimating the value of active case finding for tuberculosis in South Africa, China, and India.BMC medicine · 2014Article
- Optimizing the protection of research participants and personnel in HIV-related research where TB is prevalent: practical solutions for improving infection control.Journal of acquired immune deficiency syndromes (1999) · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The global tuberculosis (TB) control plan has historically emphasized passive case finding (PCF) as the most practical approach for identifying TB suspects in high burden settings. The success of this approach in controlling TB depends on infectious individuals recognizing their symptoms and voluntarily seeking diagnosis rapidly enough to reduce onward transmission. It now appears, at least in some settings, that more intensified case-finding (ICF) approaches may be needed to control TB transmission; these more aggressive approaches for detecting as-yet undiagnosed cases obviously require additional resources to implement. Given that TB control programs are resource constrained and that the incremental yield of ICF is expected to wane over time as the pool of undiagnosed cases is depleted, a tool that can help policymakers to identify when to implement or suspend an ICF intervention would be valuable. In this article, we propose dynamic case-finding policies that allow policymakers to use existing observations about the epidemic and resource availability to determine when to switch between PCF and ICF to efficiently use resources to optimize population health. Using mathematical models of TB/HIV coepidemics, we show that dynamic policies strictly dominate static policies that prespecify a frequency and duration of rounds of ICF. We also find that the use of a diagnostic tool with better sensitivity for detecting smear-negative cases (e.g., Xpert MTB/RIF) further improves the incremental benefit of these dynamic case-finding policies.
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Registered trials
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