ArticleProceedings of the National Academy of Sciences of the United States of America2013
The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- How Salmonella Works Under Osmotic and Desiccation Stresses.Comprehensive reviews in food science and food safety · 2026Review
- Molecular strategies ofFrontiers in cellular and infection microbiology · 2026Review
- Critical role ofApplied and environmental microbiology · 2024Article
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- The multifaceted role of c-di-AMP signaling in the regulation ofFrontiers in cellular and infection microbiology · 2024Article
- How Bacterial Pathogens Coordinate Appetite with Virulence.Microbiology and molecular biology reviews : MMBR · 2023Review
- Insights from the molecular docking analysis of colistin with the PmrA protein model from Acinetobacter baumannii.Bioinformation · 2022Article
- RNA chaperone activates Salmonella virulence program during infection.Nucleic acids research · 2021Article
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence.Nature communications · 2021Article
- A NovelFrontiers in microbiology · 2021Article
- Horizontally acquired regulatory gene activates ancestral regulatory system to promote Salmonella virulence.Nucleic acids research · 2020Article
- New Roles for Two-Component System Response Regulators ofMicroorganisms · 2020Article
- Identification of Novel Genes Mediating Survival ofFrontiers in microbiology · 2020Article
- Regulation of Iron Uptake by Fine-Tuning the Iron Responsiveness of the Iron Sensor Fur.Applied and environmental microbiology · 2019Article
- Article
- A protein that controls the onset of aThe EMBO journal · 2018Article
- Gene expression kinetics governs stimulus-specific decoration of theScience signaling · 2018Article
- Review
- Reducing Ribosome Biosynthesis Promotes Translation during Low MgMolecular cell · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The regulatory protein PmrA controls expression of lipopolysaccharide (LPS) modification genes in Salmonella enterica serovar Typhimurium, the etiologic agent of human gastroenteritis and murine typhoid fever. PmrA-dependent LPS modifications confer resistance to serum, Fe(3+), and several antimicrobial peptides, suggesting that the pmrA gene is required for Salmonella virulence. We now report that, surprisingly, a pmrA null mutant is actually hypervirulent when inoculated i.p. into C3H/HeN mice. We establish that the PmrA protein binds to the promoter and represses transcription of ssrB, a virulence regulatory gene required for expression of the Spi/Ssa type three-secretion system inside macrophages. The pmrA mutant displayed heightened expression of SsrB-dependent genes and faster Spi/Ssa-dependent macrophage killing than wild-type Salmonella. A mutation in the ssrB promoter that abolished repression by the PmrA protein rendered Salmonella as hypervirulent as the pmrA null mutant. The antivirulence function of the PmrA protein may limit the acute phase of Salmonella infection, thereby enhancing pathogen persistence in host tissues.
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