ArticleThe Journal of physiology2013
Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Non-cross Bridge Viscoelastic Elements Contribute to Muscle Force and Work During Stretch-Shortening Cycles: Evidence From Whole Muscles and Permeabilized Fibers.Frontiers in physiology · 2021Article
- The effects of fatigue and oxidation on contractile function of intact muscle fibers and myofibrils isolated from the mouse diaphragm.Scientific reports · 2019Article
- The Astonishing Behavior of Electric Eels.Frontiers in integrative neuroscience · 2019Review
- Surround inhibition can instantly be modulated by changing the attentional focus.Scientific reports · 2018Article
- Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function.Journal of muscle research and cell motility · 2017Article
- Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms.Exercise and sport sciences reviews · 2017Review
- Doublet stimulation increases CaThe Journal of general physiology · 2017Article
- Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle.The Journal of general physiology · 2017Article
- Intramuscular Contributions to Low-Frequency Force Potentiation Induced by a High-Frequency Conditioning Stimulation.Frontiers in physiology · 2017Article
- Rate of force development: physiological and methodological considerations.European journal of applied physiology · 2016Review
- An action potential-driven model of soleus muscle activation dynamics for locomotor-like movements.Journal of neural engineering · 2015Article
- Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle.Journal of muscle research and cell motility · 2015Article
- Physiological consequences of doublet discharges on motoneuronal firing and motor unit force.Frontiers in cellular neuroscience · 2015Review
- Single motor unit firing behavior in the right trapezius muscle during rapid movement of right or left index finger.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Double discharges (doublets) of motor neurones at the onset of contractions increase both force and rate of force development during voluntary submaximal contractions. The purpose of this study was to examine the role of doublet discharges on force and myoplasmic free [Ca(2+)] ([Ca(2+)]i) during repeated fatiguing contractions, using a stimulation protocol mimicking the in vivo activation pattern during running. Individual intact fibres from the flexor digitorum brevis muscle of mice were stimulated at 33°C to undergo 150 constant-frequency (five pulses at 70 Hz) or doublet (an initial, extra pulse at 200 Hz) contractions at 300 ms intervals. In the unfatigued state, doublet stimulation resulted in a transient (∼10 ms) approximate doubling of [Ca(2+)]i, which was accompanied by a greater force-time integral (∼70%) and peak force (∼40%) compared to constant frequency contractions. Moreover, doublets markedly increased force-time integral and peak force during the first 25 contractions of the fatiguing stimulation. In later stages of fatigue, addition of doublets increased force production but the increase in force production corresponded to only a minor portion of the fatigue-induced reduction in force. In conclusion, double discharges at the onset of contractions effectively increase force production, especially in early stages of fatigue. This beneficial effect occurs without additional force loss in later stages of fatigue, indicating that the additional energy cost induced by doublet discharges to skeletal muscle is limited.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.