ArticleThe American journal of tropical medicine and hygiene2013
Transmission of Onchocerca volvulus continues in Nyagak-Bondo focus of northwestern Uganda after 18 years of a single dose of annual treatment with ivermectin.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Current Gaps in Survey Design and Analysis for Molecular Xenomonitoring of Vector-Borne Neglected Tropical Diseases: A Systematic Review.Tropical medicine & international health : TM & IH · 2025Pooled it
- Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Trial
- Community-Directed Vector Control to Accelerate Onchocerciasis Elimination.Pathogens (Basel, Switzerland) · 2024Review
- Identification of the onchocerciasis vector in the Kakoi-Koda focus of the Democratic Republic of Congo.PLoS neglected tropical diseases · 2022Article
- Designing antifilarial drug trials using clinical trial simulators.Nature communications · 2020Article
- Data-driven modelling and spatial complexity supports heterogeneity-based integrative management for eliminating Simulium neavei-transmitted river blindness.Scientific reports · 2020Article
- Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs.PLoS neglected tropical diseases · 2019Article
- Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda.PLoS neglected tropical diseases · 2018Article
- Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns.Parasites & vectors · 2018Article
- Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal.Epidemics · 2017Article
- Nodding syndrome (NS) andThe Pan African medical journal · 2017Article
- Factors Associated with Ivermectin Non-Compliance and Its Potential Role in Sustaining Onchocerca volvulus Transmission in the West Region of Cameroon.PLoS neglected tropical diseases · 2016Article
- Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases.Parasites & vectors · 2015Article
- Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis.Parasites & vectors · 2015Article
- The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa.Expert review of vaccines · 2015Article
- Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections.Parasites & vectors · 2014Article
- Efficacy of three-week oxytetracycline or rifampin monotherapy compared with a combination regimen against the filarial nematode Onchocerca ochengi.Antimicrobial agents and chemotherapy · 2014Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to determine whether annual ivermectin treatment in the Nyagak-Bondo onchocerciasis focus could safely be withdrawn. Baseline skin snip microfilariae (mf) and nodule prevalence data from six communities were compared with data collected in the 2011 follow-up in seven communities. Follow-up mf data in 607 adults and 145 children were compared with baseline (300 adults and 58 children). Flies collected in 2011 were dissected, and poolscreen analysis was applied to ascertain transmission. Nodule prevalence in adults dropped from 81.7% to 11.0% (P < 0.0001), and mf prevalence dropped from 97.0% to 23.2% (P < 0.0001). In children, mf prevalence decreased from 79.3% to 14.1% (P < 0.0001). Parous and infection rates of 401 flies that were dissected were 52.9% and 1.5%, respectively, whereas the infective rate on flies examination by polymerase chain reaction (PCR) was 1.92% and annual transmission potential was 26.9. Stopping ivermectin treatment may result in onchocerciasis recrudescence.
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Registered trials
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