Evidence map›Paper›PMID 23690305›Full record

SynthesisHuman reproduction update

Genetic variants and the risk of gestational diabetes mellitus: a systematic review.

Cuilin Zhang, Wei Bao, Ying Rong, Huixia Yang, Katherine Bowers, Edwina Yeung, Michele Kiely

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 13 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 13 syntheses or guidelines pooled it, 294 citations in OpenAlex.

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  14. Trial
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  19. The Double-Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Cuilin ZhangEpidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd, Rockville, MD 20852, USA.
Wei Bao
Ying Rong
Huixia Yang
Katherine Bowers
Edwina Yeung
Michele Kiely
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · USHuazhong University of Science and Technology · CNPeking University · CN

Funding

Risk Factors of Gestational DiabetesZIAHD008889 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2009 to 2022
$1.4M
Intramural NIH HHS
6 · The paper itself

Abstract

backgroundSeveral studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We aimed to systematically review and quantitatively summarize the association of commonly studied single nucleotide polymorphisms (SNPs) with GDM risk and to identify important gaps that remain for consideration in future studies.

methodsGenetic association studies of GDM published through 1 October 2012 were searched using the HuGE Navigator and PubMed databases. A SNP was included if the SNP-GDM associations were assessed in three or more independent studies. Two reviewers independently evaluated the eligibility for inclusion and extracted the data. The allele-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using random effects models accounting for heterogeneity.

resultsOverall, 29 eligible articles capturing associations of 12 SNPs from 10 genes were included for the systematic review. The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM. Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95% CIs) of 1.44 (1.29-1.60, P < 0.001) per T allele of rs7903146 and 1.46 (1.15-1.84, P = 0.002) per T allele of rs12255372.

conclusionsIn this systematic review, we found significant associations of GDM risk with nine SNPs in seven genes, most of which have been related to the regulation of insulin secretion.

Indexed as

Polymorphism, Single NucleotideAllelesCyclin-Dependent Kinase 5Diabetes, GestationalFemaleHumansInsulinInsulin Receptor Substrate ProteinsInsulin SecretionPregnancyReceptor, Melatonin, MT1Receptor, Melatonin, MT2RiskRNA-Binding ProteinsTranscription Factor 7-Like 2 ProteintRNA MethyltransferasesCDKAL1 protein, humanCyclin-Dependent Kinase 5IGF2BP2 protein, humanInsulinInsulin Receptor Substrate ProteinsIRS1 protein, humanMTNR1B protein, humanReceptor, Melatonin, MT1Receptor, Melatonin, MT2RNA-Binding ProteinsTranscription Factor 7-Like 2 ProteintRNA Methyltransferasesgenegenetic factorsgestational diabetes mellitussingle nucleotide polymorphism

Identifiers

PMID23690305
PMCPMC3682671
OpenAlexW2132690665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.