ArticleMolecular and cellular biochemistry2013
Altered methylation of IGF2 DMR0 is associated with neural tube defects.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Multi-tissue DNA methylation analysis to identify an appropriate surrogate tissue for a unique neurological tissue specific to spina bifida.Clinical epigenetics · 2026Article
- Protective Effect of myo-Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish.Neurotoxicity research · 2025Article
- Advances in DNA methylation of imprinted genes and folic acid regulation of growth and development.Epigenomics · 2024Review
- Embryonic exposure to decitabine induces multiple neural tube defects in developing zebrafish.Fish physiology and biochemistry · 2023Article
- Abnormal methylation caused by folic acid deficiency in neural tube defects.Open life sciences · 2022Review
- Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity.JAMA network open · 2020Article
- TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.Clinical epigenetics · 2019Article
- Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons.Clinical epigenetics · 2019Article
- The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System.Biochemistry insights · 2019Review
- Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects.Epigenomics · 2018Article
- CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects.Neuroscience bulletin · 2017Article
- Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis.Epigenetics · 2017Article
- Sonic Hedgehog Signaling Affected by Promoter Hypermethylation Induces Aberrant Gli2 Expression in Spina Bifida.Molecular neurobiology · 2016Article
- Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells.Scientific reports · 2016Article
- The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.Translational psychiatry · 2016Article
- Methylome analysis for spina bifida showsClinical epigenetics · 2016Article
- Profiling placental and fetal DNA methylation in human neural tube defects.Epigenetics & chromatin · 2016Article
- Article
- A novel large deletion of the ICR1 region including H19 and putative enhancer elements.BMC medical genetics · 2015Article
- Different epigenetic alterations are associated with abnormal IGF2/Igf2 upregulation in neural tube defects.PloS one · 2014Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural tube defects (NTDs) are serious congenital malformation of fusion failure of the neural tube during early embryogenesis. DNA methylation disorders have been found in NTD-affected fetuses, and are correlated to the risk of NTDs. The insulin-like growth factor 2 (IGF2) gene, maternally imprinted, has a key role in fetal development. IGF2 transcription is partly controlled by differentially methylated regions (DMRs) 0 and 2. To assess whether disturbed methylation pattern increases the incidence of NTDs, we employed matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to quantify CpG methylation levels of DMR2 and 0 in fetuses with or without NTDs. We found that the methylation level of IGF2 DMR0 increased significantly in the brain tissues of NTD-affected fetuses. And hypermethylation of DMR0 was associated with an increased risk of NTDs, with an odds ratio of 5.375 (95 % CI: 1.447-19.965; p = 0.007). IGF2 mRNA expression was negatively correlated with the methylation level of DMR0 (R (2) = 0.893; p = 0.000) in HCT15 cells. These results highlights that IGF2 DMR0 hypermethylation is a potential risk factor of NTD, and IGF2 gene is a promising candidate gene to study for a greater understanding of the cause of NTDs.
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