Evidence map›Paper›PMID 23689685›Full record

ArticleAmerican journal of nephrology2013

Association between dietary sodium and potassium intake with chronic kidney disease in US adults: a cross-sectional study.

Shailendra Sharma, Kim McFann, Michel Chonchol, Ian H de Boer, Jessica Kendrick

Abstract read
In one paragraph

Article in American journal of nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Urine Potassium Excretion, Kidney Failure, and Mortality in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Trial
  4. Estimated potassium intake and the progression of chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  5. Serum Metabolomic Markers of Dietary Potassium and Risk of CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  6. Review
  7. Urinary Na/K ratio is a predictor of developing chronic kidney disease in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Long-term mortality and trajectory of potassium measurements following an episode of acute severe hyperkalaemia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Observational
  14. Article
  15. Spot Urine Samples to Estimate Na and K Intake in Patients With Chronic Kidney Disease and Healthy Adults: A Secondary Analysis From a Controlled Feeding Study.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2021
    Article
  16. Article
  17. Observational
  18. Nutritional management in patients with chronic kidney disease.The Korean journal of internal medicine · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shailendra SharmaDivision of Renal Diseases and Hypertension, University of Colorado Denver, Denver, CO 80204, USA.
Kim McFann
Michel Chonchol
Ian H de Boer
Jessica Kendrick

Funding

Adipokines in Hemodialysis PatientsR01DK078112 · NIDDK · UNIVERSITY OF UTAH · PI BEDDHU, SRINIVASAN · 2008 to 2011
$2.2M
Vitamin D and Clinical Outcomes in Chronic Hemodialysis PatientsR01DK081473 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CHONCHOL, MICHEL BENJAMIN · 2009 to 2012
$1.4M
Vitamin D and Arterial Function in Patients with Chronic Kidney DiseaseK23DK087859 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KENDRICK, JESSICA B · 2011 to 2015
$784k
NIDDK NIH HHS K23 DK087859NIDDK NIH HHS K23 DK087859-01A1NIDDK NIH HHS R01 DK 078112NIDDK NIH HHS R01 DK078112NIDDK NIH HHS R01 DK 081473NIDDK NIH HHS R01 DK081473
6 · The paper itself

Abstract

BACKGROUND/

aimsClinical guidelines recommend a diet low in sodium and high in potassium to reduce blood pressure and cardiovascular events. Little is known about the relationship between dietary sodium and potassium intake and chronic kidney disease (CKD).

methods13,917 participants from the National Health and Nutrition Examination Survey (2001-2006) were examined. Sodium and potassium intake were calculated from 24-hour recall and evaluated in quartiles. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2) or eGFR ≥60 ml/min/1.73 m(2) with albuminuria (>30 mg/g creatinine).

resultsThe mean (SE) age and eGFR of participants were 45.0 ± 0.4 years and 88.0 ± 0.60 ml/min/1.73 m(2), respectively. 2,333 (14.2%) had CKD: 1,146 (7.3%) had an eGFR <60 ml/min/1.73 m(2) and 1,514 (8.4%) had an eGFR ≥60 ml/min/1.73 m(2) and albuminuria. After adjustment for age, sex, race, BMI, diabetes, hypertension, cardiovascular disease and congestive heart failure, subjects in the highest quartile of sodium intake had lower odds of CKD compared to subjects in the lowest quartile (adjusted OR: 0.79; 95% CI: 0.66-0.96; p < 0.016). Compared to the highest quartile, the odds of CKD increased 44% for participants in the lowest quartile of potassium intake (adjusted OR: 1.44; 95% CI: 1.16-1.79; p = 0.0011).

conclusionsHigher intake of sodium and potassium is associated with lower odds of CKD among US adults. These results should be corroborated through longitudinal studies and clinical trials designed specifically to examine the effects of dietary sodium and potassium intake on kidney disease and its progression.

Indexed as

Potassium, DietarySodium, DietaryAdultAlbuminuriaCohort StudiesCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleMiddle AgedNutrition SurveysOdds RatioRenal Insufficiency, ChronicUnited StatesPotassium, DietarySodium, Dietary

Identifiers

PMID23689685
PMCPMC3919025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.