ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
BDNF overexpression in the ventral tegmental area prolongs social defeat stress-induced cross-sensitization to amphetamine and increases ΔFosB expression in mesocorticolimbic regions of rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Cross-talk between the HPA axis and addiction-related regions in stressful situations.Heliyon · 2023Review
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.Addiction biology · 2020Article
- Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression.Biological psychiatry · 2019Review
- VTA BDNF enhances social stress-induced compulsive cocaine bingeing.Oncotarget · 2017Article
- Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat.Neuropharmacology · 2016Article
- Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sex differences in drug addiction and response to exercise intervention: From human to animal studies.Frontiers in neuroendocrinology · 2016Review
- Article
- The Effects of Psychological Stress on Depression.Current neuropharmacology · 2015Review
- Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents.Frontiers in neuroanatomy · 2015Article
- Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse.Neuroscience · 2014Review
- Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inhibitory effect of NMDA receptors in the ventral tegmental area on hormonal and eating behavior responses to stress in rats.Behavioural neurology · 2014Article
- Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment.Frontiers in behavioral neuroscience · 2014Article
- Early Life Stress Associated With Increased StriatalChronic stress (Thousand Oaks, Calif.)Article
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6 authors at 4 institutions in 1 country.
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Abstract
Social defeat stress induces persistent cross-sensitization to psychostimulants, but the molecular mechanisms underlying the development of cross-sensitization remain unclear. One candidate is brain-derived neurotrophic factor (BDNF). The present research examined whether ventral tegmental area (VTA) BDNF overexpression would prolong the time course of cross-sensitization after a single social defeat stress, which normally produces transient cross-sensitization lasting <1 week. ΔFosB, a classic molecular marker of addiction, was also measured in mesocorticolimbic terminal regions. Separate groups of intact male Sprague-Dawley rats underwent a single episode of social defeat stress or control handling, followed by amphetamine (AMPH) challenge 3 or 14 days later. AMPH cross-sensitization was apparent 3, but not 14, days after stress. Intra-VTA infusion of adeno-associated viral (AAV-BDNF) vector resulted in a twofold increase of BDNF level in comparison to the group receiving the control virus (AAV-GFP), which lasted at least 45 days. Additionally, overexpression of BDNF in the VTA alone increased ΔFosB in the nucleus accumbens (NAc) and prefrontal cortex. Fourteen days after viral infusions, a separate group of rats underwent a single social defeat stress or control handling and were challenged with AMPH 14 and 24 days after stress. AAV-BDNF rats exposed to stress showed prolonged cross-sensitization and facilitated sensitization to the second drug challenge. Immunohistochemistry showed that the combination of virally enhanced VTA BDNF, stress, and AMPH resulted in increased ΔFosB in the NAc shell compared with the other groups. Thus, elevation of VTA BDNF prolongs cross-sensitization, facilitates sensitization, and increases ΔFosB in mesocorticolimbic terminal regions. As such, elevated VTA BDNF may be a risk factor for drug sensitivity.
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