ArticleContributions to nephrology2013
Physiological biomarkers of acute kidney injury: a conceptual approach to improving outcomes.
Article in Contributions to nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- The renoprotective effects of gallic acid on cisplatin-induced nephrotoxicity through anti-apoptosis, anti-inflammatory effects, and downregulation of lncRNA TUG1.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Red Blood Cell Dysfunction in Critical Illness.Critical care clinics · 2020Review
- Physiology and technology for the ICU in vivo.Critical care (London, England) · 2019Review
- A Novel Hybrid Cytokine IL233 Mediates regeneration following Doxorubicin-Induced Nephrotoxic Injury.Scientific reports · 2019Article
- Drug management in acute kidney disease - Report of the Acute Disease Quality Initiative XVI meeting.British journal of clinical pharmacology · 2018Article
- Article
- Personalized physiological medicine.Critical care (London, England) · 2017Review
- Intensive care medicine in 2050: the ICU in vivo.Intensive care medicine · 2017Article
- Transfusion Decision Making in Pediatric Critical Illness.Pediatric clinics of North America · 2017Review
- Renal Oxygenation and Hemodynamics in Kidney Injury.Nephron · 2017Review
- Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients.Critical care (London, England) · 2016Article
- High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion.Kidney international · 2016Article
- Targeting Endogenous Repair Pathways after AKI.Journal of the American Society of Nephrology : JASN · 2016Review
- Acute kidney injury in acute on chronic liver failure.Hepatology international · 2016Review
- Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- The Complex Relationship of Extracorporeal Membrane Oxygenation and Acute Kidney Injury: Causation or Association?BioMed research international · 2016Review
- Renal Hemodynamics in AKI: In Search of New Treatment Targets.Journal of the American Society of Nephrology : JASN · 2016Article
- Association of inflammatory and endothelial cell activation biomarkers with acute kidney injury after sepsis.SpringerPlus · 2014Article
- Biology of renal recovery: molecules, mechanisms, and pathways.Nephron. Clinical practice · 2014Review
- Contrast media viscosity versus osmolality in kidney injury: lessons from animal studies.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The past 5-10 years have brought significant advances in the identification and validation of novel biochemical biomarkers in the prevention and treatment of acute kidney injury (AKI). These biochemical biomarkers remain research tools but we anticipate that soon they will be employed in clinical practice. A Consensus Conference held by the Acute Dialysis Quality Initiative (ADQI) recently reviewed the evidence, and identified gaps and a research agenda. Furthermore, at this meeting was the birth of an initiative to comprehensively identify new opportunities to characterize the physiological changes during the course of AKI based upon a conceptual framework for the detection and monitoring of renal ischemia-reperfusion injury. This framework includes a transition from monitoring physiological biomarkers of adequate renal perfusion, to pathophysiologic biomarkers of renal hypoperfusion, and finally biomarkers of kidney cell structural injury/damage. Techniques to measure physiological changes in AKI include several physiological variables that might be used in an interactive way to supplement clinical information and biochemical damage biomarkers in the diagnosis and management of AKI. This review summarizes the spectrum of physiological parameters and potential new physiological methods that enable identification of high-risk patients for AKI, facilitate early diagnosis, and differential diagnosis to guide therapeutic management and prognostication. Finally, we propose a research agenda for the next 5 years to facilitate the development and validation of physiological biomarkers in AKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.