Trial reportEuropean journal of nutrition2014
Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide(1-42), glucagon-like peptide-1 and insulin concentrations in humans.
Trial report in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01986036 (The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity.The Journal of clinical endocrinology and metabolism · 2025Trial
- Trial
- Effects of physical form ofThe British journal of nutrition · 2024Trial
- Whey protein consumption following fasted exercise reduces early postprandial glycaemia in centrally obese males: a randomised controlled trial.European journal of nutrition · 2021Trial
- The Postprandial Glycaemic and Hormonal Responses Following the Ingestion of a Novel, Ready-to-Drink Shot Containing a Low Dose of Whey Protein in Centrally Obese and Lean Adult Males: A Randomised Controlled Trial.Frontiers in endocrinology · 2021Trial
- Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.European journal of applied physiology · 2020Trial
- The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial.Food and nutrition bulletin · 2020Trial
- Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults.European journal of nutrition · 2020Trial
- Trial
- Acute effects of calcium supplements on blood pressure: randomised, crossover trial in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Trial
- Milk consumption following exercise reduces subsequent energy intake in female recreational exercisers.Nutrients · 2015Trial
- The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial.European journal of clinical nutrition · 2014Trial
- Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion.Endocrine reviews · 2026Review
- Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations.Journal of bone metabolism · 2024Article
- Role of prior feeding status in mediating the effects of exercise on blood glucose kinetics.American journal of physiology. Cell physiology · 2023Review
- A perspective on the benefits of consumption of parboiled rice over brown rice for glycaemic control.European journal of nutrition · 2022Review
- Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2021Review
- A critical review of the role of milk and other dairy products in the development of obesity in children and adolescents.Nutrition research reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study determined whether calcium co-ingestion potentiates postprandial GIP(1-42) and GLP-1 concentrations in humans and the concomitant impact on insulin, appetite sensations and substrate metabolism.
methodsTen healthy males consumed two energy- and macronutrient-matched meals in a double-blind, randomized, crossover design. The calcium content of the control meal was 3 mg/kg body mass, which was increased to 15 mg/kg body mass with calcium co-ingestion. Circulating concentrations of GIP(1-42), GLP-1 and insulin were determined over a 180-min postprandial period, followed by 60 min of exercise. Visual analogue scales were used to determine subjective appetite sensations. Rates of energy expenditure and substrate (lipid and carbohydrate) oxidation were estimated using indirect calorimetry.
resultsCalcium co-ingestion resulted in a 47% increase in GIP(1-42), a 22% increase in GLP-1 and a 19% increase in insulin areas under the curve for the 120 min following consumption (all P < 0.05). Furthermore, appetite sensations were suppressed by calcium co-ingestion by 12% (P = 0.034). No differences, however, were observed in substrate metabolism (P > 0.05).
conclusionIngestion of a high-calcium meal potentiates postprandial GIP(1-42), GLP-1 and insulin concentrations in humans. Subjective appetite is also temporarily suppressed, although substrate metabolism is unaffected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.