ArticleCell research2013
RhoGTPases--NODes for effector-triggered immunity in animals.
Article in Cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity.PLoS pathogens · 2025Review
- The Cytotoxic Necrotizing Factors (CNFs)-A Family of Rho GTPase-Activating Bacterial Exotoxins.Toxins · 2021Review
- RhoGTPases and inflammasomes: Guardians of effector-triggered immunity.PLoS pathogens · 2021Review
- CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.Pathogens and disease · 2018Review
- Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis.Small GTPases · 2015Review
- Detection of enteric pathogens by the nodosome.Trends in immunology · 2014Review
- Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions.Cell communication and signaling : CCS · 2014Review
- Rho family GTPase-dependent immunity in plants and animals.Frontiers in plant science · 2014Review
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Authors and funding
2 authors.
Funding
Abstract
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.