ArticleBiochemical and biophysical research communications2013
A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway.Scientific reports · 2023Article
- SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.The journal of headache and pain · 2023Article
- Role of PGC-1α in Mitochondrial Quality Control in Neurodegenerative Diseases.Neurochemical research · 2019Review
- A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs.Frontiers in pharmacology · 2019Article
- N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes.Molecular medicine reports · 2018Article
- Cell-Specific Deletion of PGC-1α from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.Annals of clinical and translational neurology · 2017Article
- Expression of PGC1α in glioblastoma multiforme patients.Oncology letters · 2017Article
- Diabetes and Cognitive Impairment.Current diabetes reports · 2016Review
- Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.Experimental neurobiology · 2014Review
- Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.Mitochondrion · 2014Article
- Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.Annals of clinical and translational neurology · 2014Article
- Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins.Molecular bioSystems · 2014Article
- PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy.Neurobiology of disease · 2014Article
- SIRT3: as simple as it seems?Gerontology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Peroxisome proliferator-activated receptor-gamma co-activator 1α (PGC-1α) and PTEN-induced putative kinase 1 (PINK1) are powerful regulators of mitochondrial function. Here, we report that a previously unrecognized, novel 35 kDa PGC-1α isoform localizes to the mitochondrial inner membrane and matrix in brain as determined by protease protection and carbonate extraction assays, as well as by immunoelectron microscopy. Immunoelectron microscopy and import experiments in vitro revealed that 35 kDa PGC-1α colocalizes and interacts with the voltage-dependent anion channel (VDAC), and that its import depends on VDAC. Valinomycin treatment which depolarizes the membrane potential, abolished mitochondrial localization of the 35 kDa PGC-1α. Using blue native-PAGE, co-immunoprecipitation, and immunoelectron microscopy analyses, we found that the 35 kDa PGC-1α binds and colocalizes with PINK1 in brain mitochondria. This is the first report regarding mitochondrial localization of a novel 35 kDa PGC-1α isoform and its association with PINK1, suggesting possible regulatory roles for mitochondrial function in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.