ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2013
Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2.Frontiers in pharmacology · 2020Review
- Study of Combined Ultrasound-microwave Effect on Chemical Compositions andIranian journal of pharmaceutical research : IJPR · 2018Article
- Effectiveness of Liquid-Liquid Extraction, Solid Phase Extraction, and Headspace Technique for Determination of Some Volatile Water-Soluble Compounds of Rose Aromatic Water.International journal of analytical chemistry · 2017Article
- Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Cardiotonic Drugs from the Avicenna's Point of View.Iranian journal of public health · 2015Article
- In Vitro Impact of Hydro-alcoholic Extract of Rosa damascena Mill. on Rat Ileum Contractions and the Mechanisms Involved.International journal of preventive medicine · 2014Article
- Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach.Journal of toxicology · 2013Article
- Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe possible mechanism(s) of inotropic and chronotropic effects of the extract from Rosa damascena (R. damascena) on heart was examined.
methodsInotropic and chronotropic effects of four concentrations of the extract from R. damascena and isoprenaline were examined in isolated guinea-pig hearts perfused through aorta in a Langendorff model. All measurements were performed in three different groups: 1) In the presence and absence of propranolol, 2) In the presence and absence of methacholine and 3) In the presence of diltiazem (n = 12 for each group).
resultsIn all groups both isoprenaline and the extract caused an increase in heart rate and contractility (p < 0.05 to p < 0.001). Only in group 1, the final concentration of isoprenaline in the absence of propranolol caused significant greater increase in heart rate compared to the extract (207.6 ± 11.0 compared to 162.6 ± 11.8, p < 0.01). The percent increase in heart contractility due to the final concentration of the extract in the absence (362.4 ± 36.9 compared to 227.7 ± 31.6, p < 0.01) and presence of propranolol (577.1 ± 62.9 compared to 357.5 ± 45.6, p < 0.001) in group 1 and absence (403.7 ± 42.1 compared to 244.8 ± 18.9, p < 0.005) and presence of methcholine (499.88 ± 64.64 compared to 323.90 ± 44.49, p < 0.05) in groups 2 was significantly greater than the increase caused by isoprenaline.
conclusionsThe results of this study suggest that inotropic and chornotropic effect of R. damascena is possibly due to the stimulatory effect of this plant on beta-adrenoceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.