ArticleMolecular pain2013
Voluntary movements as a possible non-reflexive pain assay.
Article in Molecular pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 36 citations in OpenAlex.
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- Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.Neuron · 2023Article
- Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.Scientific reports · 2022Article
- Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain-related behavior.JOR spine · 2022Article
- Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain.JCI insight · 2022Article
- Liquid Biopsy-Based Biomarkers of Inflammatory Nociception Identified in Male Rats.Frontiers in pharmacology · 2022Article
- Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain.Scientific reports · 2021Article
- Effects of Ketoprofen and Morphine on Pain-Related Depression of Nestlet Shredding in Male and Female Mice.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls.The Journal of pharmacology and experimental therapeutics · 2021Article
- Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice.Arthritis research & therapy · 2021Article
- Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors.Scientific reports · 2020Article
- Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats.Scientific reports · 2020Article
- Intrathecal Oxytocin Improves Spontaneous Behavior and Reduces Mechanical Hypersensitivity in a Rat Model of Postoperative Pain.Frontiers in pharmacology · 2020Article
- A Review of Pain Assessment Methods in Laboratory Rodents.Comparative medicine · 2019Review
- Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.The Journal of experimental medicine · 2019Article
- Open field and a behavior score in PNT model for neuropathic pain in pigs.Journal of pain research · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe quantification of pain intensity in vivo is essential for identifying the mechanisms of various types of pain or for evaluating the effects of different analgesics. A variety of behavioral tests for pain measurement have been devised, but many are limited because animals are physically restricted, which affects pain sensation. In this study, pain assessment was attempted with minimal physical restriction, and voluntary movements of unrestrained animals were used to evaluate the intensities of various types of pain.
resultsThe number of times animals reared or total distances traveled was measured using a motion-tracking device and found to be markedly reduced in carrageenan-induced inflammatory, acetic acid-induced visceral, and streptozotocin-induced neuropathic pain tests. These two voluntary movement parameters were found to be highly correlated with paw withdrawal latency from irradiating heat. In addition, these parameters were markedly reversed by morphine and by non-steroidal anti-inflammatory drugs in inflammatory pain models. These parameters were also useful to detect hypoalgesia in TRPV1⁻/⁻ mice.
conclusionsThese results suggest that parameters of voluntary movement, such as, number of rearing and total distance moved, are effective indicators of pain intensity for many types of pain and that they can be used to evaluate degree of pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.