ArticleJournal of bacteriology2013
Temporal expression program of quorum sensing-based transcription regulation in Sinorhizobium meliloti.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A systems-level insight into PHB-driven metabolic adaptation orchestrated by the PHB-binding transcriptional regulator AniA (PhaR).mSystems · 2025Article
- Unexpected modulation of Hna phage defense activity by the symbiotic regulator NolR.Journal of bacteriology · 2025Article
- Unraveling the small proteome of the plant symbiontmicroLife · 2023Article
- Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies.Plants (Basel, Switzerland) · 2022Review
- Frequency modulation of a bacterial quorum sensing response.Nature communications · 2022Article
- Maturation of UTR-Derived sRNAs Is Modulated during Adaptation to Different Growth Conditions.International journal of molecular sciences · 2021Article
- Biocontrol of Biofilm Formation: Jamming of Sessile-Associated Rhizobial Communication by Rhodococcal Quorum-Quenching.International journal of molecular sciences · 2021Article
- Deciphering the Symbiotic Significance of Quorum Sensing Systems ofMicroorganisms · 2020Article
- A high-throughput system to identify inhibitors ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Bifunctional UDP-Sugar 4-Epimerase Supports Biosynthesis of Multiple Cell Surface Polysaccharides in Sinorhizobium meliloti.Journal of bacteriology · 2019Article
- Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis.Genes · 2018Review
- Novel Genes and Regulators That Influence Production of Cell Surface Exopolysaccharides in Sinorhizobium meliloti.Journal of bacteriology · 2018Article
- Water-Soluble Humic Materials Regulate Quorum Sensing inFrontiers in microbiology · 2018Article
- Unraveling RubisCO Form I and Form II Regulation in an Uncultured Organism from a Deep-Sea Hydrothermal Vent via Metagenomic and Mutagenesis Studies.Frontiers in microbiology · 2017Article
- Quorum Sensing Communication Modules for Microbial Consortia.ACS synthetic biology · 2016Article
- Chemotaxis signaling systems in model beneficial plant-bacteria associations.Plant molecular biology · 2016Review
- Cyclic Di-GMP Regulates Multiple Cellular Functions in the Symbiotic Alphaproteobacterium Sinorhizobium meliloti.Journal of bacteriology · 2016Article
- The Sinorhizobium meliloti SyrM regulon: effects on global gene expression are mediated by syrA and nodD3.Journal of bacteriology · 2015Article
- A stress-induced small RNA modulates alpha-rhizobial cell cycle progression.PLoS genetics · 2015Article
- Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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4 authors.
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Abstract
The Sin quorum sensing (QS) system of S. meliloti activates exopolysaccharide and represses flagellum production. The system consists of an N-acyl-homoserine lactone (AHL) synthase, SinI, and at least two LuxR-type regulators, SinR and ExpR. SinR appears to be independent of AHLs for its control of sinI expression, while ExpR is almost completely dependent upon AHLs. In this study, we confirmed 7 previously detected ExpR-DNA binding sites and used the consensus sequence to identify another 26 sites, some of which regulate genes previously not known to be members of the ExpR/AHL regulon. The activities of promoters dependent upon ExpR/AHL were titrated against AHL levels, with varied outcomes in AHL sensitivity. The data suggest a type of temporal expression program whereby the activity of each promoter is subject to a specific range of AHL concentrations. For example, genes responsible for exopolysaccharide production are activated at lower concentrations of AHLs than those required for the repression of genes controlling flagellum production. Several features of ExpR-regulated promoters appear to determine their response to AHLs. The location of the ExpR-binding site with respect to the relevant transcription start within each promoter region determines whether ExpR/AHL activates or represses promoter activity. Furthermore, the strength of the response is dependent upon the concentration of AHLs. We propose that this differential sensitivity to AHLs provides a bacterial colony with a transcription control program that is dynamic and precise.
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