ArticlePediatric pulmonology2013
Multiple-flow exhaled nitric oxide, allergy, and asthma in a population of older children.
Article in Pediatric pulmonology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Impact of systemic steroids on asthma biomarkers: A comprehensive analysis.The World Allergy Organization journal · 2026Review
- Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.BMJ open respiratory research · 2023Article
- Longitudinal hierarchical Bayesian models of covariate effects on airway and alveolar nitric oxide.Scientific reports · 2023Article
- Asthma clustering methods: a literature-informed application to the children's health study data.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Review
- Long-term exposures to air pollutants affectThe European respiratory journal · 2021Article
- Impact of different fixed flow sampling protocols on flow-independent exhaled nitric oxide parameter estimates using the Bayesian dynamic two-compartment model.Physiological reports · 2020Article
- Serum Levels of Epithelial-Derived Cytokines as Interleukin-25 and Thymic Stromal Lymphopoietin after a Single Dose of Mepolizumab in Patients with Severe Non-Allergic Eosinophilic Asthma: A Short Report.Canadian respiratory journal · 2019Article
- Bayesian estimation of physiological parameters governing a dynamic two-compartment model of exhaled nitric oxide.Physiological reports · 2017Article
- Optimal flow rate sampling designs for studies with extended exhaled nitric oxide analysis.Journal of breath research · 2017Article
- [Research progress in relationship between fractional exhaled nitric oxide and asthma in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Traffic-related air pollution and alveolar nitric oxide in southern California children.The European respiratory journal · 2016Article
- Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease.Pediatric research · 2016Article
- An Overview of Fractional Exhaled Nitric Oxide and Children with Asthma.Expert review of clinical immunology · 2016Review
- Spirometry effects on conventional and multiple flow exhaled nitric oxide in children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2015Article
- Elevated levels of exhaled nitric oxide in patients with anorexia nervosa.European child & adolescent psychiatry · 2014Article
- Alveolar nitric oxide and its role in pediatric asthma control assessment.BMC pulmonary medicine · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
unlabelled"Extended" (multiple-flow) measurements of exhaled nitric oxide (FeNO) potentially can distinguish proximal and distal airway inflammation, but have not been evaluated previously in large populations. We performed extended NO testing within a longitudinal study of a school-based population, to relate bronchial flux (J'awNO) and peripheral NO concentration (CalvNO) estimates with respiratory health status determined from questionnaires. We measured FeNO at 30, 50, 100, and 300 ml/sec in 1,640 subjects aged 12-15 from eight communities, then estimated J'awNO and CalvNO from linear and nonlinear regressions of NO output versus flow. J'awNO, as well as FeNO at all flows, showed influences of asthma, allergy, Asian or African ancestry, age, and height (positive), and of weight (negative), generally corroborating past findings. By contrast, CalvNO results were inconsistent across different extended NO regression models, and appeared more sensitive to small measurement artifacts.
conclusionsExtended NO testing is feasible in field surveys of young populations. In interpreting results, size, age, and ethnicity require attention, as well as instrumental and environmental artifacts. J'awNO and conventional FeNO provide similar information, probably reflecting proximal airway inflammation. CalvNO may give additional information relevant to peripheral airway, alveolar, or systemic pathology. However, it needs additional research, including testing of populations with independently verifiable peripheral or systemic pathology, to optimize measurement technique and interpretation.
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