ArticleJournal of the American Medical Informatics Association : JAMIA
Epilepsy and seizure ontology: towards an epilepsy informatics infrastructure for clinical research and patient care.
Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Natural language processing systems for capturing and standardizing unstructured clinical information: A systematic review.Journal of biomedical informatics · 2017Pooled it
- Developing a Specialized Dravet Syndrome Ontology for Rare Disease Informatics and AI Applications.medRxiv : the preprint server for health sciences · 2026Article
- Epilepsy disease classification: a community effort to enhance the Mondo Disease Ontology.Database : the journal of biological databases and curation · 2026Article
- Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy.International journal of medical informatics · 2025Article
- Semiology Extraction and Machine Learning-Based Classification of Electronic Health Records for Patients With Epilepsy: Retrospective Analysis.JMIR medical informatics · 2024Article
- Clinical Research Informatics: a Decade-in-Review.Yearbook of medical informatics · 2024Review
- Transforming Ontology Web Language Elements into Common Terminology Service 2 Terminology Resources.Journal of personalized medicine · 2024Article
- Whole-cycle management of women with epilepsy of child-bearing age: ontology construction and application.BMC medical informatics and decision making · 2024Article
- Towards building a trustworthy pipeline integrating Neuroscience Gateway and Open Science Chain.Database : the journal of biological databases and curation · 2024Article
- Design of the formalized and integrated Alzheimer's Disease Ontology and its application in retrieving textual data via text mining.Database : the journal of biological databases and curation · 2023Article
- Principles and Standards for Designing and Managing Integrable and Interoperable Transformed Health Ecosystems.Journal of personalized medicine · 2023Article
- Extracting Temporal Expressions of First Seizure Onset from Epilepsy Patient Discharge Summaries.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023Article
- The Epilepsy Ontology: a community-based ontology tailored for semantic interoperability and text mining.Bioinformatics advances · 2023Article
- Ontology-based feature engineering in machine learning workflows for heterogeneous epilepsy patient records.Scientific reports · 2022Article
- Ontology-based identification and prioritization of candidate drugs for epilepsy from literature.Journal of biomedical semantics · 2022Review
- The Representation of Causality and Causation with Ontologies: A Systematic Literature Review.Online journal of public health informatics · 2022Review
- A multimodal clinical data resource for personalized risk assessment of sudden unexpected death in epilepsy.Frontiers in big data · 2022Article
- Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable.Epilepsia · 2021Article
- Can Big Data guide prognosis and clinical decisions in epilepsy?Epilepsia · 2021Review
- A Bespoke Electronic Health Record for Epilepsy Care (EpiToMe): Development and Qualitative Evaluation.Journal of medical Internet research · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveEpilepsy encompasses an extensive array of clinical and research subdomains, many of which emphasize multi-modal physiological measurements such as electroencephalography and neuroimaging. The integration of structured, unstructured, and signal data into a coherent structure for patient care as well as clinical research requires an effective informatics infrastructure that is underpinned by a formal domain ontology.
methodsWe have developed an epilepsy and seizure ontology (EpSO) using a four-dimensional epilepsy classification system that integrates the latest International League Against Epilepsy terminology recommendations and National Institute of Neurological Disorders and Stroke (NINDS) common data elements. It imports concepts from existing ontologies, including the Neural ElectroMagnetic Ontologies, and uses formal concept analysis to create a taxonomy of epilepsy syndromes based on their seizure semiology and anatomical location.
resultsEpSO is used in a suite of informatics tools for (a) patient data entry, (b) epilepsy focused clinical free text processing, and (c) patient cohort identification as part of the multi-center NINDS-funded study on sudden unexpected death in epilepsy. EpSO is available for download at http://prism.case.edu/prism/index.php/EpilepsyOntology. DISCUSSION: An epilepsy ontology consortium is being created for community-driven extension, review, and adoption of EpSO. We are in the process of submitting EpSO to the BioPortal repository.
conclusionsEpSO plays a critical role in informatics tools for epilepsy patient care and multi-center clinical research.
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