ArticleAmerican journal of medical genetics. Part A2013
Descriptive epidemiology of idiopathic clubfoot.
Article in American journal of medical genetics. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 99 citations in OpenAlex.
- Contemporary national treatment patterns for clubfoot relapse-related interventions: a large multi-institutional cohort.BMC musculoskeletal disorders · 2026Observational
- Pearls and Pitfalls of Ponseti Method Bracing for Idiopathic Clubfoot-An Institutional Guide to Optimize Orthotic Management.Journal of the Pediatric Orthopaedic Society of North America · 2026Review
- 3D steady-state free precession in fetal body MR imaging: A useful adjunctive sequence.Acta radiologica open · 2026Article
- Management of Relapsed, Residual, and Resistant Idiopathic Congenital Talipes Equinovarus.Journal of orthopaedic case reports · 2026Article
- Developmental Outcomes in Children With Clubfoot: A Twin Study Comparing Affected and Unaffected Siblings.Journal of pediatric orthopedics · 2025Article
- The perspectives of caregivers and health service providers on barriers to clubfoot management in Puri-Urban health facility in Ghana.Journal of children's orthopaedics · 2024Article
- Continuous nursing for infants with congenital talipes equinovarus undergoing Ponseti therapy and telehealth education for their parents via WeChat: a single center retrospective study.Frontiers in public health · 2024Article
- Trends in congenital clubfoot prevalence and co-occurring anomalies during 1994-2021 in Denmark: a nationwide register-based study.BMC musculoskeletal disorders · 2023Article
- EVALUATION OF EARLY TREATMENT OF IDIOPATHIC CLUBFOOT USING THE PONSETI METHOD.Acta ortopedica brasileira · 2023Article
- Congenital talipes equinovarus: A literature review.Annals of medicine and surgery (2012) · 2022Review
- Relapse in surgically treated clubfoot: treatment approach and midterm results of revision surgery.Acta bio-medica : Atenei Parmensis · 2022Article
- Incidence of Congenital Clubfoot: Preliminary Data from Italian CeDAP Registry.International journal of environmental research and public health · 2022Article
- Outcome of prenatal diagnosis of clubfoot: a single institution experience.Future science OA · 2022Article
- Genetic association and characterization of FSTL5 in isolated clubfoot.Human molecular genetics · 2021Article
- Improving musculoskeletal health for children and young people - A 'call to action'.Best practice & research. Clinical rheumatology · 2020Review
- Global prevalence estimates of three chronic musculoskeletal conditions: club foot, juvenile idiopathic arthritis and juvenile systemic lupus erythematosus.Pediatric rheumatology online journal · 2020Article
- Early management of clubfoot by the Ponseti method with complete percutaneous tenotomy of tendoachillis.Journal of family medicine and primary care · 2019Article
- First trimester physiological development of the fetal foot position using three-dimensional ultrasound in virtual reality.The journal of obstetrics and gynaecology research · 2019Article
- Clinical outcomes and risk-factor analysis of the Ponseti Method in a low-resource setting: Clubfoot care in Haiti.PloS one · 2019Article
- Club foot in association with the 22q11.2 deletion syndrome: An observational study.American journal of medical genetics. Part A · 2018Observational
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Clubfoot is a common structural malformation, occurring in approximately 1/1,000 live births. Previous studies of sociodemographic and pregnancy-related risk factors have been inconsistent, with the exception of the strong male preponderance and association with primiparity. Hypotheses for clubfoot pathogenesis include fetal constraint, Mendelian-inheritance, and vascular disruption, but its etiology remains elusive. We conducted a population-based case-control study of clubfoot in North Carolina, Massachusetts, and New York from 2007 to 2011. Mothers of 677 clubfoot cases and 2,037 non-malformed controls were interviewed within 1 year of delivery about socio-demographic and reproductive factors. Cases and controls were compared for child's sex, maternal age, education, cohabitation status, race/ethnicity, state, gravidity, parity, body mass index (BMI), and these pregnancy-related conditions: oligohydramnios, breech delivery, bicornuate uterus, plural birth, early amniocentesis (<16 weeks), chorionic villous sampling (CVS), and plural gestation with fetal loss. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for state. Cases were more likely to be male (OR: 2.7; 2.2-3.3) and born to primiparous mothers (1.4; 1.2-1.7) and mothers with BMI ≥30 kg/m(2) (1.4; 1.1-1.8). These associations were greatest in isolated and bilateral cases. ORs for the pregnancy-related conditions ranged from 1.3 (breech delivery) to 5.6 (early amniocentesis). Positive associations with high BMI were confined to cases with a marker of fetal constraint (oligohydramnios, breech delivery, bicornuate uterus, plural birth), inheritance (family history in 1st degree relative), or vascular disruption (early amniocentesis, CVS, plural gestation with fetal loss). Pathogenetic factors associated with obesity may be in the causal pathway for clubfoot.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.