ArticleProceedings of the National Academy of Sciences of the United States of America2013
Assessment of multidrug resistance on cell coculture patterns using scanning electrochemical microscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 82 citations in OpenAlex.
- Taking Charge Against the Silent Pandemic-Electrochemical Characterization of Drug Resistance.Molecules (Basel, Switzerland) · 2026Review
- Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid-β Plaques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CytochromeProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Temperature Effect on the Electrochemical Current Response during Scanning Electrochemical Microscopy of Living Cells.Analytical chemistry · 2023Article
- Investigating the cytotoxic redox mechanism of PFOS within Hep G2 by hyperspectral-assisted scanning electrochemical microscopy.The Analyst · 2022Article
- Article
- Enhancing scanning electrochemical microscopy's potential to probe dynamic co-culture systemsThe Analyst · 2022Article
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.FEBS open bio · 2020Observational
- Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles.Nature communications · 2019Article
- Correlating Live Cell Viability with Membrane Permeability Disruption Induced by Trivalent Chromium.ACS omega · 2019Article
- Review
- Recent Advances in Scanning Electrochemical Microscopy for Biological Applications.Materials (Basel, Switzerland) · 2018Review
- A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes.Chemical science · 2018Article
- Electrochemical recognition and quantification of cytochrome c expression inChemical science · 2017Article
- MicroRNA-134 reverses multidrug resistance in human lung adenocarcinoma cells by targeting FOXM1.Oncology letters · 2017Article
- Achieving reproducible performance of electrochemical, folding aptamer-based sensors on microelectrodes: challenges and prospects.Analytical chemistry · 2014Article
- Microstamped Petri dishes for scanning electrochemical microscopy analysis of arrays of microtissues.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of resistance to multiple unrelated chemotherapeutic drugs impedes the treatment of several cancers. Although the involvement of ATP-binding cassette transporters has long been known, there is no in situ method capable of tracking this transporter-related resistance at the single-cell level without interfering with the cell's environment or metabolism. Here, we demonstrate that scanning electrochemical microscopy (SECM) can quantitatively and noninvasively track multidrug resistance-related protein 1-dependent multidrug resistance in patterned adenocarcinoma cervical cancer cells. Nonresistant human cancer cells and their multidrug resistant variants are arranged in a side-by-side format using a stencil-based patterning scheme, allowing for precise positioning of target cells underneath the SECM sensor. SECM measurements of the patterned cells, performed with ferrocenemethanol and [Ru(NH3)6](3+) serving as electrochemical indicators, are used to establish a kinetic "map" of constant-height SECM scans, free of topography contributions. The concept underlying the work described herein may help evaluate the effectiveness of treatment administration strategies targeting reduced drug efflux.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.