Evidence map›Paper›PMID 23686527›Full record

ArticleThe Psychiatric quarterly2013

Case reports of neuroleptic malignant syndrome in context of quetiapine use.

Mark B Detweiler, Kelly Sullivan, Taral R Sharma, Kye Y Kim, Jonna G Detweiler

Abstract read
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In one paragraph

Article in The Psychiatric quarterly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark B DetweilerPsychiatry Service, Veterans Affairs Medical Center, 1970 Roanoke Boulevard (116A7), Salem, VA, 24153, USA, mark.detweiler1@va.gov.
Kelly Sullivan
Taral R Sharma
Kye Y Kim
Jonna G Detweiler
Virginia Tech · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A retrospective analysis was followed on 20 case reports covering the possible correlation between the atypical antipsychotic, quetiapine, and neuroleptic malignant syndrome (NMS), determined by the study of 7 different NMS criteria guidelines. A great majority (19) of the case studies did not meet the requirements of all 7 guidelines, frequently due to unreported information. Nor was quetiapine proven to be the sole cause of the possible NMS in the two age groups investigated. Only one case was found to have no other medication or medical conditions confounding the relationship of quetiapine and NMS symptoms, and that case was in the context of a significant quetiapine overdose. The other 19 cases demonstrated the difficulty of identifying the cause of NMS when polypharmacy and other medical conditions are involved. The authors note the need for caution in deciding both the presence of NMS and the causal factors of the symptoms.

Indexed as

Neuroleptic Malignant SyndromeAdultAge FactorsAntiparkinson AgentsAntipsychotic AgentsDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersDibenzothiazepinesDose-Response Relationship, DrugFeverGuideline AdherenceHumansMental DisordersMiddle AgedMuscle RigidityPractice Guidelines as TopicAntiparkinson AgentsAntipsychotic AgentsDibenzothiazepinesQuetiapine FumarateSelective Serotonin Reuptake Inhibitors

Identifiers

PMID23686527
OpenAlexW2048862108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.