ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
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- Evaluation of Thymic Output and Regulatory T Cells in Kidney Transplant Recipients with Chronic Antibody-Mediated Rejection.BioMed research international · 2021Article
- Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.Nature communications · 2020Article
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The full spectrum of human naive T cells.Nature reviews. Immunology · 2018Review
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes.The Journal of experimental medicine · 2016Article
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- Improving cancer immunotherapy with DNA methyltransferase inhibitors.Cancer immunology, immunotherapy : CII · 2016Review
- Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.Aging cell · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent thymic emigrants (RTEs) are the youngest T cells in the lymphoid periphery and exhibit phenotypic and functional characteristics distinct from those of their more mature counterparts in the naive peripheral T cell pool. We show in this study that the Il2 and Il4 promoter regions of naive CD4(+) RTEs are characterized by site-specific hypermethylation compared with those of both mature naive (MN) T cells and the thymocyte precursors of RTEs. Thus, RTEs do not merely occupy a midpoint between the thymus and the mature T cell pool, but represent a distinct transitional T cell population. Furthermore, RTEs and MN T cells exhibit distinct CpG DNA methylation patterns both before and after activation. Compared with MN T cells, RTEs express higher levels of several enzymes that modify DNA methylation, and inhibiting methylation during culture allows RTEs to reach MN T cell levels of cytokine production. Collectively, these data suggest that the functional differences that distinguish RTEs from MN T cells are influenced by epigenetic mechanisms and provide clues to a mechanistic basis for postthymic maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.