Evidence map›Paper›PMID 23686390›Full record

ArticleStatistics in medicine2013

Rank-based principal stratum sensitivity analyses.

X Lu, D V Mehrotra, B E Shepherd

Abstract read
In one paragraph

Article in Statistics in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

X LuDepartment of Biostatistics, University of Florida, Gainesville, FL, 32610, U.S.A.
D V Mehrotra
B E Shepherd

Funding

PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
Statistical Methods for Ordinal Variables in HIV/AIDS StudiesR01AI093234 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chun Li, Bryan Earl Shepherd · 2011 to 2026
$4.9M
NCI NIH HHS UM1 CA182883NIAID NIH HHS R01 AI093234
6 · The paper itself

Abstract

We describe rank-based approaches to assess principal stratification treatment effects in studies where the outcome of interest is only well-defined in a subgroup selected after randomization. Our methods are sensitivity analyses, in that estimands are identified by fixing a parameter and then we investigate the sensitivity of results by varying this parameter over a range of plausible values. We present three rank-based test statistics and compare their performance through simulations, and provide recommendations. We also study three different bootstrap approaches for determining levels of significance. Finally, we apply our methods to two studies: an HIV vaccine trial and a prostate cancer prevention trial.

Indexed as

Data Interpretation, StatisticalTreatment OutcomeAIDS VaccinesComputer SimulationFinasterideHIV InfectionsHumansMaleProstatic NeoplasmsAIDS VaccinesFinasteridecausal inferencemonotonicitynon-normalityprincipal stratificationranks

Identifiers

PMID23686390
PMCPMC5753805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.