ArticleScience (New York, N.Y.)2013
Point-counterpoint. Ethics and genomic incidental findings.
Registry-linked trialAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01736566 (The MedSeq Project Pilot Study), which is not on this map. Cited by 90 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The MedSeq Project Pilot Study: Integrating Whole Genome Sequencing Into the Practice of Clinical Medicine
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Pooled it
- Newborn Sequencing in Genomic Medicine and Public Health.Pediatrics · 2017Trial
- Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.Annals of internal medicine · 2016Trial
- When bins blur: Patient perspectives on categories of results from clinical whole genome sequencing.AJOB empirical bioethicsTrial
- Pharmacovigilance in Cell and Gene Therapy: Evolving Challenges in Risk Management and Long-Term Follow-Up.Drug safety · 2026Review
- Normative Issues in Next Generation Sequencing Gene Testing.Development & reproduction · 2023Article
- Newborn Screening for the Diagnosis and Treatment of Duchenne Muscular Dystrophy.Journal of neuromuscular diseases · 2023Review
- Privacy and ethical challenges of the Amelogenin sex test in forensic paternity/kinship analysis: Insights from a 13-year case history.Forensic science international. Synergy · 2023Article
- Public interest in unexpected genomic findings: a survey study identifying aspects of sequencing attitudes that influence preferences.Journal of community genetics · 2022Article
- From newborn screening to genomic medicine: challenges and suggestions on how to incorporate genomic newborn screening in public health programs.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2022Article
- Opportunistic genomic screening. Recommendations of the European Society of Human Genetics.European journal of human genetics : EJHG · 2021Article
- Perceptions of best practices for return of results in an international survey of psychiatric genetics researchers.European journal of human genetics : EJHG · 2021Article
- Practices and Attitudes toward Returning Genomic Research Results to Low-Resource Research Participants.Public health genomics · 2021Article
- Next-Generation Sequencing in Newborn Screening: A Review of Current State.Frontiers in genetics · 2021Review
- Attitudes toward and current status of disclosure of secondary findings from next-generation sequencing: a nation-wide survey of clinical genetics professionals in Japan.Journal of human genetics · 2020Article
- An ethical framework for genetic counseling in the genomic era.Journal of genetic counseling · 2020Article
- Predictive Analytics and the Return of "Research" Information to Participants.Applied Human Factors and Ergonomics Conference · 2020Article
- Article
- A proposal on the first Japanese practical guidance for the return of individual genomic results in research settings.Journal of human genetics · 2020Article
- Ethical values supporting the disclosure of incidental and secondary findings in clinical genomic testing: a qualitative study.BMC medical ethics · 2020Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Amy L McGuireCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu
Steven Joffe
Barbara A Koenig
Barbara B Biesecker
Laurence B McCullough
Jennifer S Blumenthal-Barby
Timothy Caulfield
Sharon F Terry
Robert C Green
Funding
Measuring Perceptions of Utility of Clinical Genome Sequencing: Instrument Testing and ValidationU01HG006485 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI MCGUIRE, AMY L, PARSONS, DONALD W. · 2012 to 2021
$22.1MIntegration of Whole Genome Sequencing into Clinical MedicineU01HG006500 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C. · 2012 to 2016
$11.5MRisk Evaluation and Education for Alzheimer's Disease (REVEAL IV)R01HG002213 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C. · 1999 to 2012
$7.6MThe Use of Whole-Exome Sequencing to Guide the Care of Cancer PatientsU01HG006492 · NHGRI · DANA-FARBER CANCER INST · PI JANNE, PASI A, VAN ALLEN, ELIEZER M · 2012 to 2016
$7.3MDisclosing Genomic Incidental Findings in a Cancer Biobank: An ELSI ExperimentR01CA154517 · NCI · MAYO CLINIC ROCHESTER · PI KOENIG, BARBARA A., PETERSEN, GLORIA M. · 2011 to 2015
$2.7MManaging Incidental Findings in Human Subjects ResearchR01HG003178 · NHGRI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WOLF, SUSAN M. · 2005 to 2010
$1.5MImpact of Direct to Consumer Genetic TestingR01HG005092 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C., ROBERTS, SCOTT · 2010 to 2012
$1.1MCenter for Transdisciplinary ELSI Research in Translational GenomicsP20HG007243 · NHGRI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HARRIS-WAI, JULIE NOEL, KOENIG, BARBARA A. · 2013 to 2016
$958kReturning Research Results of Pediatric Genomic Research to ParticipantsR21HG006612 · NHGRI · VANDERBILT UNIVERSITY · PI CLAYTON, ELLEN WRIGHT · 2011 to 2012
$389kReturning research results in children: Parental Preferences and Expert OversightR01HG006615 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI HOLM, INGRID ADELE · 2011 to 2013
$361kIntramural NIH HHSNCI NIH HHS CA154517NCI NIH HHS R01 CA154517NCI NIH HHS R01-CA154517NHGRI NIH HHS HG003178NHGRI NIH HHS HG005092NHGRI NIH HHS HG006485NHGRI NIH HHS HG006492NHGRI NIH HHS HG006500NHGRI NIH HHS HG006612-02NHGRI NIH HHS HG006615NHGRI NIH HHS HG02213NHGRI NIH HHS P20 HG007243NHGRI NIH HHS R01 HG002213NHGRI NIH HHS R01 HG003178NHGRI NIH HHS R01 HG005092NHGRI NIH HHS R01 HG006615NHGRI NIH HHS R21 HG006612NHGRI NIH HHS U01 HG006485NHGRI NIH HHS U01 HG006492NHGRI NIH HHS U01 HG006500
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genetic Predisposition to DiseaseIncidental FindingsPractice Guidelines as TopicAdultChildDiseaseGenetic TestingGenome-Wide Association StudyGenomicsHumansLaboratoriesMutationNeoplasmsSequence Analysis, DNA
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01736566ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.