Evidence map›Paper›PMID 23686314›Full record

ArticleOncogene2014

Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis.

Z Ding, M Joy, R Bhargava, M Gunsaulus, N Lakshman, M Miron-Mendoza, M Petroll, J Condeelis, A Wells, P Roy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 62 citations in OpenAlex.

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  8. Prognostic model based on B cell marker genes for NSCLC patients under neoadjuvant immunotherapy by integrated analysis of single-cell and bulk RNA-sequencing data.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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  14. Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Z DingDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
M JoyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
R Bhargava1] Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA [2] Magee Women's Hospital, Pittsburgh, Pittsburgh, PA, USA.
M GunsaulusDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
N LakshmanDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
M Miron-MendozaDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
M PetrollDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J CondeelisDepartment of Cell Biology and Anatomy, Albert Einstein College of Medicine, New York, NY, USA.
A Wells1] Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA [3] McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
P Roy1] Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA [3] McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA [4] Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USThe University of Texas Southwestern Medical Center · USAlbert Einstein College of Medicine · US

Funding

Profilin as a target to suppress Invasive breast cancerR01CA108607 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROY, PARTHA · 2006 to 2017
$2.6M
NCI NIH HHS 2R01CA108607-07NCI NIH HHS R01 CA108607
6 · The paper itself

Abstract

Profilin1 (Pfn1), a ubiquitously expressed actin-binding protein, has an indispensable role in migration and proliferation of normal cells. Seemingly contrary to its essential cellular functions, Pfn1's expression is downregulated in breast cancer, the significance of which is unclear. In this study, expression profiling of Pfn1 in human breast cancer specimens correlates lower Pfn1 expression levels with propensity to metastasize. Xenograft experiments further establish a causal relationship between loss of Pfn1 expression and increased dissemination of breast cancer cells (BCCs) from the primary mammary tumor. BCCs exhibit a hyperinvasive phenotype (marked by matrix metalloproteinase-9 upregulation, faster invasion through collagen matrix) and acquire increased proficiency to transmigrate through endothelial barrier (an obligatory step for vascular dissemination) when Pfn1 expression is suppressed. In Pfn1-deficient cells, hyperinvasiveness involves a phosphatidylinositol 3-kinase-PI(3,4)P2 signaling axis while augmented transendothelial migration occurs in a vascular endothelial growth factor-dependent manner. Contrasting these dissemination promoting activities, loss of Pfn1, however, dramatically inhibits metastatic outgrowth of disseminated BCCs, suggesting that Pfn1 has a key role in the metastatic colonization process. In summary, this study shows that Pfn1 has a dichotomous role in early vs late steps of breast cancer metastasis.

Indexed as

Down-RegulationGene Expression Regulation, NeoplasticAnimalsBreast NeoplasmsCell Line, TumorFemaleHumansImmunoblottingImmunohistochemistryMatrix Metalloproteinase 9Mice, NudeNeoplasm MetastasisPhosphatidylinositol 3-KinasesPhosphatidylinositolsProfilinsReverse Transcriptase Polymerase Chain ReactionMatrix Metalloproteinase 9Phosphatidylinositol 3-KinasesPhosphatidylinositolsphosphoinositide-3,4-bisphosphateProfilins

Identifiers

PMID23686314
PMCPMC3834125
OpenAlexW2006437070

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.