ArticleJournal of computational neuroscience2013
A single compartment model of pacemaking in dissasociated substantia nigra neurons: stability and energy analysis.
Article in Journal of computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Quantitative Systems Pharmacology Development and Application in Neuroscience.Handbook of experimental pharmacology · 2025Review
- Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases.Journal of pharmacokinetics and pharmacodynamics · 2024Review
- Hallmarks of neurodegenerative disease: A systems pharmacology perspective.CPT: pharmacometrics & systems pharmacology · 2022Review
- Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration.Scientific reports · 2021Article
- Mathematical Biology Models of Parkinson's Disease.CPT: pharmacometrics & systems pharmacology · 2019Review
- The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions.CPT: pharmacometrics & systems pharmacology · 2017Review
- Implications of cellular models of dopamine neurons for disease.Journal of neurophysiology · 2016Review
- MEIGO: an open-source software suite based on metaheuristics for global optimization in systems biology and bioinformatics.BMC bioinformatics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous oscillations in the mid-brain dopaminergic neurons are an important feature of motor control. The degeneration of these neurons is involved in movement disorders, particularly Parkinson's Disease. Modelling of this activity is an important part of developing an understanding of the pathogenic process. We develop a mathematical paradigm to describe this activity with a single compartment approach and a CellML version is made publicly available. The model explicitly describes the dynamics of the transmembrane potential with changes in the levels of important cations and is consistent with two major observations in the literature regarding its behaviour in the presence of channel blockers. Stability of the model behaviour is determined from the properties of its Monodromy matrix. We also discuss from the perspective of energy, a pharmacological intervention suggested in the treatment of Parkinson's Disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.