ArticleMycopathologia2013
The predominance of alternatively activated macrophages following challenge with cell wall peptide-polysaccharide after prior infection with Sporothrix schenckii.
Article in Mycopathologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Current Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- IL-18 favors Th2 responses in sporotrichosis caused by Sporothrix globosa, prolonging the course of the disease.PLoS neglected tropical diseases · 2025Article
- Innate Immune Responses to Sporothrix schenckii: Recognition and Elimination.Mycopathologia · 2023Review
- Differential Recognition ofInfection and drug resistance · 2023Article
- Current Models to Study theFrontiers in fungal biology · 2022Review
- The Role of Macrophages in the Host's Defense againstPathogens (Basel, Switzerland) · 2021Review
- Murine Macrophage Requires CD11b to RecognizeInfection and drug resistance · 2020Article
- Sporotrichosis In Immunocompromised Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Immunopathogenesis of Human Sporotrichosis: What We Already Know.Journal of fungi (Basel, Switzerland) · 2018Review
- Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice.BMC microbiology · 2017Article
- Molecular Components of the Sporothrix schenckii Complex that Induce Immune Response.Current microbiology · 2016Review
- Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection.Mycopathologia · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporotrichosis is a subcutaneous mycosis that is caused by the dimorphic fungus Sporothrix schenckii. This disease generally occurs within the skin and subcutaneous tissues, causing lesions that can spread through adjacent lymphatic vessels and sometimes leading to systemic diseases in immunocompromised patients. Macrophages are crucial for proper immune responses against a variety of pathogens. Furthermore, macrophages can play different roles in response to different microorganisms and forms of activation, and they can be divided into "classic" or "alternatively" activated populations, as also known as M1 and M2 macrophages. M1 cells can lead to tissue injury and contribute to pathogenesis, whereas M2 cells promote angiogenesis, tissue remodeling, and repair. The aim of this study was to investigate the roles of M1 and M2 macrophages in a sporotrichosis model. Toward this end, we performed phenotyping of peritoneal exudate cells and evaluated the concomitant production of several immunomediators, including IL-12, IL-10, TGF-β, nitric oxide, and arginase-I activity, which were stimulated ex vivo with cell wall peptide-polysaccharide. Our results showed the predominance of the M2 macrophage population, indicated by peaks of arginase-I activity as well as IL-10 and TGF-β production during the 6th and 8th weeks after infection. These results were consistent with cellular phenotyping that revealed increases in CD206-positive cells over this period. This is the first report of the participation of M2 macrophages in sporotrichosis infections.
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