ArticleEnvironmental toxicology and pharmacology2013
Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
Article in Environmental toxicology and pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure-Preliminary In Vivo Study.Toxics · 2022Article
- Converging Effects of Three Different Endocrine Disrupters on Sox and Pou Gene Expression in Developing Rat Hippocampus: Possible Role of microRNA in Sex Differences.Frontiers in genetics · 2021Article
- Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.Nature communications · 2020Article
- Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations.Environment international · 2019Article
- ZebrafishBiology open · 2019Article
- Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture.Environmental health perspectives · 2018Article
- Thyroid-disrupting chemicals and brain development: an update.Endocrine connections · 2018Review
- Environmental Mechanisms of Neurodevelopmental Toxicity.Current environmental health reports · 2018Review
- Article
- Exposure to agricultural pesticide impairs visual lateralization in a larval coral reef fish.Scientific reports · 2017Article
- Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints.Environmental health : a global access science source · 2016Article
- Toxic chemicals and thyroid function: hard facts and lateral thinking.Reviews in endocrine & metabolic disorders · 2015Review
- Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor.Neurotoxicology and teratologyArticle
- Histopathological features of low-dose organophosphate exposure.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although organophosphate pesticides are not usually characterized as "endocrine disruptors," recent work points to potential, long-term reductions of circulating thyroid hormones after developmental exposures to chlorpyrifos that are devoid of observable toxicity. We administered chlorpyrifos to developing rats on gestational days 17-20 or postnatal days 1-4, regimens that produce distinctly different, sex-selective effects on neurobehavioral performance. The prenatal regimen produced a small, but statistically significant reduction in brain thyroxine levels from juvenile stages through adulthood; in contrast, postnatal exposure produced a transient elevation in young adulthood. However, in neither case did we observe the sex-selectivity noted earlier for neurobehavioral outcomes of these specific treatment regimens, or as reported earlier for effects on serum T4 in developing mice. Thus, although chlorpyrifos has the potential to disrupt thyroid status sufficiently to alter brain thyroid hormone levels, the effect is small, and any potential contribution to neurobehavioral abnormalities remains to be proven.
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