Evidence map›Paper›PMID 23685995›Full record

ReviewCold Spring Harbor perspectives in biology2013

Human papillomavirus infections: warts or cancer?

Louise T Chow, Thomas R Broker

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. p16Infectious agents and cancer · 2023
    Article
  6. Article
  7. Article
  8. Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Targeting DNA Damage Response as a Strategy to Treat HPV Infections.International journal of molecular sciences · 2019
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Louise T ChowDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.
Thomas R Broker
University of Alabama at Birmingham · US

Funding

MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATIONR01CA083679 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHOW, LOUISE T · 1999 to 2015
$5.1M
Mechanisms of HPV DNA SegregationR01CA107338 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHOW, LOUISE T · 2004 to 2008
$1.7M
HUMAN PAPILLOMAVIRUS GENE EXPRESSIONR01CA036200 · NCI · UNIVERSITY OF ROCHESTER · PI BROKER, THOMAS R · 1985 to 2003
$1.4M
NCI NIH HHS CA107338NCI NIH HHS CA36200NCI NIH HHS CA83679NCI NIH HHS R01 CA036200NCI NIH HHS R01 CA083679NCI NIH HHS R01 CA107338
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) are prevalent pathogens of mucosal and cutaneous epithelia. Productive infections of squamous epithelia lead to benign hyperproliferative warts, condylomata, or papillomas. Persistent infections of the anogenital mucosa by high-risk HPV genotypes 16 and 18 and closely related types can infrequently progress to high-grade intraepithelial neoplasias, carcinomas-in-situ, and invasive cancers in women and men. HPV-16 is also associated with a fraction of head and neck cancers. We discuss the interactions of the mucosotropic HPVs with the host regulatory proteins and pathways that lead to benign coexistence and enable HPV DNA amplification or, alternatively, to cancers that no longer support viral production.

Indexed as

AlphapapillomavirusFemaleGenome, ViralGenotypeHost-Pathogen InteractionsHumansMalePapillomavirus InfectionsUterine Cervical NeoplasmsVirus ReplicationWarts

Identifiers

PMID23685995
PMCPMC3685896
OpenAlexW2141452772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.