ReviewCellular and molecular life sciences : CMLS2013
Social environmental effects on gene regulation.
Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Spectrum of Peripheral-Vestibular Deficits and Their Change Over Time in CANVAS/RFC1-Related Ataxia Systematic Review and Meta-Analysis of Quantitative Head-Impulse Testing.Cerebellum (London, England) · 2025Pooled it
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- Reporting and representation of population descriptors in public RNA-seq databases.Cell genomics · 2026Article
- The use of race terms in epigenetics research: considerations moving forward.Frontiers in genetics · 2024Article
- Interpretable deep learning for improving cancer patient survival based on personal transcriptomes.Scientific reports · 2023Article
- Social Determinants of Health and Cerebral Small Vessel Disease: Is Epigenetics a Key Mediator?Journal of the American Heart Association · 2023Review
- Systemic Inflammation Contributes to the Association Between Childhood Socioeconomic Disadvantage and Midlife Cardiometabolic Risk.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Understanding Health Inequalities Through the Lens of Social Epigenetics.Annual review of public health · 2022Review
- Article
- MKK7 deficiency in mature neurons impairs parental behavior in mice.Genes to cells : devoted to molecular & cellular mechanisms · 2021Article
- Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain.Journal of molecular neuroscience : MN · 2020Article
- Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cutting-edge genetics in obsessive-compulsive disorder.Faculty reviews · 2020Review
- Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain.American journal of human genetics · 2019Article
- Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques.Biology letters · 2019Article
- Combined Effects Of Low Incubation Temperature, Minimal Growth Medium, And Low Hydrodynamics OptimizeInfection and drug resistance · 2019Article
- Dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional genomic insights into the environmental determinants of mammalian fitness.Current opinion in genetics & development · 2018Review
- Genomic responses to the socio-sexual environment in maleRNA (New York, N.Y.) · 2017Article
- Socio-Genomics and Structural Competency.Journal of bioethical inquiry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Social environmental conditions, particularly the experience of social adversity, have long been connected with health and mortality in humans and other social mammals. Efforts to identify the physiological basis for these effects have historically focused on their neurological, endocrinological, and immunological consequences. Recently, this search has been extended to understanding the role of gene regulation in sensing, mediating, and determining susceptibility to social environmental variation. Studies in laboratory rodents, captive primates, and human populations have revealed correlations between social conditions and the regulation of a large number of genes, some of which are likely causal. Gene expression responses to the social environment are, in turn, mediated by a set of underlying regulatory mechanisms, of which epigenetic marks are the best studied to date. Importantly, a number of genes involved in the response to the social environment are also associated with susceptibility to other external stressors, as well as certain diseases. Hence, gene regulatory studies are a promising avenue for understanding, and potentially developing strategies to address, the effects of social adversity on health.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.