ArticleIntegrative biology : quantitative biosciences from nano to macro2013
Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.
Article in Integrative biology : quantitative biosciences from nano to macro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain.bioRxiv : the preprint server for biology · 2025Article
- Maternal lipid mobilization is essential for embryonic development in the malaria vector Anopheles gambiae.PLoS biology · 2024Article
- Precise coordination between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae.PLoS genetics · 2024Article
- Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles.PLoS pathogens · 2023Article
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Nature communications · 2023Article
- Article
- Substrate-based kinase activity inference identifies MK2 as driver of colitis.Integrative biology : quantitative biosciences from nano to macro · 2019Article
- A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes.Scientific reports · 2018Article
- Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.Cell reports · 2017Article
- Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.Diabetologia · 2016Article
- The DIONESUS algorithm provides scalable and accurate reconstruction of dynamic phosphoproteomic networks to reveal new drug targets.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Multiscale analysis of the murine intestine for modeling human diseases.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Mining the function of protein tyrosine phosphatases in health and disease.Seminars in cell & developmental biology · 2015Review
- Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.Cell metabolism · 2014Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b(-/-)) suggest that hepatic PTP1b inhibition would mitigate metabolic-syndrome through amelioration of hepatic insulin resistance, endoplasmic-reticulum stress, and whole-body lipid metabolism. However, the altered molecular-network states underlying these phenotypes are poorly understood. We used mass spectrometry to quantify protein-phosphotyrosine network changes in L-PTP1b(-/-) mouse livers relative to control mice on normal and high-fat diets. We applied a phosphosite-set-enrichment analysis to identify known and novel pathways exhibiting PTP1b- and diet-dependent phosphotyrosine regulation. Detection of a PTP1b-dependent, but functionally uncharacterized, set of phosphosites on lipid-metabolic proteins motivated global lipidomic analyses that revealed altered polyunsaturated-fatty-acid (PUFA) and triglyceride metabolism in L-PTP1b(-/-) mice. To connect phosphosites and lipid measurements in a unified model, we developed a multivariate-regression framework, which accounts for measurement noise and systematically missing proteomics data. This analysis resulted in quantitative models that predict roles for phosphoproteins involved in oxidation-reduction in altered PUFA and triglyceride metabolism.
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