ArticleNature neuroscience2013
Synaptic mechanisms of adaptation and sensitization in the retina.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- A standard model for the vertebrate retina.Vision research · 2026Article
- Shared-Scale Predictive Benchmarking of an Acoustic-Radiation-Force Model for Frequency-Dependent Retinal Ganglion Cell Responses.Bioengineering (Basel, Switzerland) · 2026Article
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- Adaptation of visual responses in degeneratingFrontiers in neuroscience · 2026Article
- Article
- Relative Role of ON/OFF Pathways in Resolving and Adapting to Blur in Myopes and Emmetropes.Investigative ophthalmology & visual science · 2025Article
- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- Behavioral Profiling in Zebrafish Identifies Insecticide-Related Compounds.Journal of agricultural and food chemistry · 2025Article
- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Article
- Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses.Nature communications · 2024Article
- GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.Cognitive neurodynamics · 2024Article
- Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina.Cell reports · 2023Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Calibrating Vision: Concepts and Questions.Vision research · 2022Review
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.Nature communications · 2022Article
- Functional-pathway-dominant contrast adaptation and sensitization in mouse retinal ganglion cells.Cognitive neurodynamics · 2020Article
- Correction of z-motion artefacts to allow population imaging of synaptic activity in behaving mice.The Journal of physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Sensory systems continually adjust the way stimuli are processed. What are the circuit mechanisms underlying this plasticity? We investigated how synapses in the retina of zebrafish adjust to changes in the temporal contrast of a visual stimulus by imaging activity in vivo. Following an increase in contrast, bipolar cell synapses with strong initial responses depressed, whereas synapses with weak initial responses facilitated. Depression and facilitation predominated in different strata of the inner retina, where bipolar cell output was anticorrelated with the activity of amacrine cell synapses providing inhibitory feedback. Pharmacological block of GABAergic feedback converted facilitating bipolar cell synapses into depressing ones. These results indicate that depression intrinsic to bipolar cell synapses causes adaptation of the ganglion cell response to contrast, whereas depression in amacrine cell synapses causes sensitization. Distinct microcircuits segregating to different layers of the retina can cause simultaneous increases or decreases in the gain of neural responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.