ArticleJournal of visualized experiments : JoVE2013
Controlled cervical laceration injury in mice.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice.Experimental neurology · 2022Article
- Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury.JCI insight · 2022Article
- Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice.Neural regeneration research · 2021Article
- In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury.Cell stem cell · 2021Article
- Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals.Frontiers in neurology · 2019Article
- The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice.Journal of visualized experiments : JoVE · 2017Article
- A novel vertebral stabilization method for producing contusive spinal cord injury.Journal of visualized experiments : JoVE · 2015Article
- Intravital imaging of axonal interactions with microglia and macrophages in a mouse dorsal column crush injury.Journal of visualized experiments : JoVE · 2014Article
- Technical comments on rodent spinal cord injuries models.Neural regeneration research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Use of genetically modified mice enhances our understanding of molecular mechanisms underlying several neurological disorders such as a spinal cord injury (SCI). Freehand manual control used to produce a laceration model of SCI creates inconsistent injuries often associated with a crush or contusion component and, therefore, a novel technique was developed. Our model of cervical laceration SCI has resolved inherent difficulties with the freehand method by incorporating 1) cervical vertebral stabilization by vertebral facet fixation, 2) enhanced spinal cord exposure, and 3) creation of a reproducible laceration of the spinal cord using an oscillating blade with an accuracy of ± 0.01 mm in depth without associated contusion. Compared to the standard methods of creating a SCI laceration such as freehand use of a scalpel or scissors, our method has produced a consistent lesion. This method is useful for studies on axonal regeneration of corticospinal, rubrospinal, and dorsal ascending tracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.