ArticleNeurosurgery2013
A case series of primary central nervous system posttransplantation lymphoproliferative disorder: imaging and clinical characteristics.
Article in Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Radiological and FDG-PET imaging features of Epstein-Barr virus-positive primary central nervous system lymphomas.Journal of neurology · 2026Article
- Immunity Gone Viral: Subacute Cognitive Decline With Multifocal Brain Lesions in Neuromyelitis Optica Spectrum Disorder.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Time Is Key: Early Diagnosis of Post-Transplant Lymphoproliferative Disorder Presenting as Primary CNS Diffuse Large B-Cell Lymphoma.Current oncology (Toronto, Ont.) · 2026Article
- Central nervous system post-transplant lymphoproliferative disorder relapse after pediatric liver transplantation: a case report and literature review.Translational pediatrics · 2026Article
- Case Report: Post-transplant lymphoproliferative disorder mimicking Baló's concentric sclerosis.Frontiers in oncology · 2026Article
- Primary central nervous system lymphomas in immunocompromised patients require specific response criteria.Journal of neuro-oncology · 2024Article
- Primary central nervous system post-transplantation lymphoproliferative disorder: A case report and systematic review of imaging findings.Radiology case reports · 2024Article
- Neuroimaging features of primary central nervous system post-transplantation lymphoproliferative disorder following hematopoietic stem cell transplant in patients with β-thalassemia: a case series and review of literature.Insights into imaging · 2024Article
- A disease warranting attention from neurosurgeons: primary central nervous system post-transplant lymphoproliferative disorder.Frontiers in neurology · 2024Article
- An Unusual Presentation of Posterior Reversible Encephalopathy Syndrome Following Liver Transplantation.Transplantation direct · 2022Article
- The spectrum of Epstein-Barr virus infections of the central nervous system after organ transplantation.Virology journal · 2021Review
- Successful treatment of central nervous system lymphoproliferative disorder in a kidney-pancreas and stem cell transplanted patient using intrathecal rituximab.BMJ case reports · 2021Article
- Late-Onset Posttransplant Lymphoproliferative Disorders after Solid Organ Transplantation in Adults: A Case Series and Review of the Literature.Case reports in transplantation · 2020Article
- Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential.Insights into imaging · 2019Review
- Complete and Durable Responses in Primary Central Nervous System Posttransplant Lymphoproliferative Disorder with Zidovudine, Ganciclovir, Rituximab, and Dexamethasone.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Primary Central Nervous System Post-transplant Lymphoproliferative Disorder Diagnosed by Peripheral Facial Nerve Palsy.Internal medicine (Tokyo, Japan) · 2018Article
- Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Article
- A Rare Presentation of Isolated CNS Posttransplantation Lymphoproliferative Disorder.Case reports in oncological medicine · 2017Article
- Posterior Reversible Encephalopathy Syndrome After Transplantation: a Review.Molecular neurobiology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrimary central nervous system posttransplantation lymphoproliferative disorder (PCNS-PTLD) is a rare complication after solid organ transplantation (SOT). With increasing rates of SOT, PCNS-PTLD incidence is increasing.
objectiveTo describe the characteristics of PCNS-PTLD patients requiring neurosurgical intervention.
methodsFrom 2000 to 2011, 10 patients with prior SOT underwent biopsy for evaluation of brain lesions and were diagnosed with PCNS-PTLD. Data collected included imaging characteristics, pathology, treatments administered, and survival outcomes.
resultsAll patients had kidney transplantation, and 3 had concurrent pancreas transplantation. Median age at diagnosis was 49 years, with a median of 4.5 years from SOT to diagnosis (range, 1.8-11.4 years). Presenting symptoms most often included focal neurological deficits (n = 6), although several patients had nonspecific symptoms of headache and altered mental status. Brain lesions were generally multiple (n = 7), supratentorial (n = 8), and lobar or periventricular in distribution with ring enhancement. Diagnosis was established by stereotactic (n = 4) and open surgical (n = 6) biopsy. Treatments most frequently administered included reduction of immunosuppression (n = 10), dexamethasone (n = 10), rituximab (n = 8), high-dose methotrexate (n = 3), and whole-brain radiotherapy (n = 6). Six patients remain alive without PCNS-PTLD relapse, including 4 patients who have sustained remissions beyond 2 years from diagnosis of PCNS-PTLD. Of 4 observed deaths, 1 was related to progressive PCNS-PTLD.
conclusionPCNS-PTLD must be considered in the differential diagnosis of any patient with prior SOT presenting with an intracranial lesion. Histological diagnosis with brain biopsy is imperative, given the risk for opportunistic infections that may have similar imaging findings and presentation. Prognosis is variable, although long-term survival has been reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.