ArticleCellular immunology2013
Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis.
Article in Cellular immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A prospective single centre pilot evaluation of a serum calprotectin assay in unselected GI patients.Clinical biochemistry · 2017Trial
- Peiminine attenuates inflammatory bowel disease by suppressing TLR4 mediated NFƙB pathway: an integrated network pharmacology and experimental validation.Scientific reports · 2026Article
- A CRISPR mediated point-of-care assay for the detection of mucosal calprotectin in an animal model of ulcerative colitis.Bioengineering & translational medicine · 2025Article
- Ameliorative effect of nodakenin in combating TNBS-induced ulcerative colitis by suppressing NFƙB-mediated NLRP3 inflammasome pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Gut permeability, circulating bacterial fragments and measures of congestion in peritoneal dialysis.Clinical kidney journal · 2024Article
- Serum vascular endothelial growth factor has diagnostic and prognostic significance in ulcerative colitis.Turkish journal of medical sciences · 2024Article
- A Pilot Clinical Study on Post-Operative Recurrence Provides Biological Clues for a Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- Estrogen Receptor β as a Candidate Regulator of Sex Differences in the Maternal Immune Activation Model of ASD.Frontiers in molecular neuroscience · 2021Review
- Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep.BMC veterinary research · 2019Article
- The Costs of Living Together: Immune Responses to the Microbiota and Chronic Gut Inflammation.Applied and environmental microbiology · 2019Review
- Inflammatory bowel diseases: time of diagnosis, environmental factors, clinical course, and management - a follow-up study in a private inflammatory bowel disease center (2003-2017).Journal of inflammation research · 2019Article
- Ischemic colitis of the colon in streptozotocin-induced diabetic rats.Molecular and cellular biochemistry · 2018Article
- T-Bet Is Dependent on Stat-4 Inhibiting Acute Colitis but Not Stat-1 Using L4 Somatic Antigen ofTheScientificWorldJournal · 2018Article
- Serum Calprotectin: A Novel Diagnostic and Prognostic Marker in Inflammatory Bowel Diseases.The American journal of gastroenterology · 2016Article
- The TNBS-induced colitis animal model: An overview.Annals of medicine and surgery (2012) · 2016Review
- Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes.Journal of human lactation : official journal of International Lactation Consultant Association · 2016Article
- Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia.Science translational medicine · 2015Article
- Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.Journal of proteomics · 2015Article
- Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease: correlations and 5-year mortality - a cohort study.Journal of inflammation (London, England) · 2015Article
- Serum Calprotectin in Rheumatoid Arthritis: A Promising Diagnostic Marker, How Far Is It Related to Activity and Sonographic Findings?Journal of medical ultrasoundArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimSerum calprotectin is elevated in patients with inflammatory bowel disease (IBD). Whether it correlates other markers of disease activity is unknown. The aim of this study was to correlate serum calprotectin with biochemical and histological measures of intestinal inflammation. MATERIALS AND
methodsTNBS colitis was induced in wistar rats, and serial blood samples were collected at 0, 3, and 12 days. Animals were subsequently sacrificed for pathological evaluation at day 12. Serum calprotectin and cytokines were measured by ELISA. Pathologic changes were classified at the macroscopic and microscopic levels.
resultsTNBS colitis induced elevated serum calprotectin, TNF and IL-6 within 24 h. Levels of serum calprotectin remained elevated in parallel to persistence of loose stool and weight loss to day 12. Serum calprotectin levels correlated with serum levels of TNF-α and IL6 (p < 0.001), but not CRP. Animals with liquid stool had significantly higher levels of serum calprotectin than control animals. There was a correlation between macroscopic colitis scores, and levels of serum calprotectin.
conclusionSerum calprotectin levels correlate with biochemical and histological markers of inflammation in TNBS colitis. This biomarker may have potential for diagnostic use in patients with IBD.
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