ArticlePain2013
Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.
Article in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain.Neuron · 2023Article
- Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice.Frontiers in pharmacology · 2022Article
- Pharmacological restoration of anti-nociceptive functions in the prefrontal cortex relieves chronic pain.Progress in neurobiology · 2021Article
- Frequency Dependent Electrical Stimulation of PFC and ACC for Acute Pain Treatment in Rats.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.Cell death & disease · 2020Article
- Article
- AMPAkines and morphine provide complementary analgesia.Behavioural brain research · 2017Article
- Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond.Neural plasticity · 2017Review
- Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn.Neuroscience · 2016Article
- Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets.Spinal cord · 2016Review
- Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain.Current medicinal chemistry · 2016Review
- Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.Molecular autism · 2016Article
- Upregulation of Homer1a Promoted Retinal Ganglion Cell Survival After Retinal Ischemia and Reperfusion via Interacting with Erk Pathway.Cellular and molecular neurobiology · 2015Article
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Review
- Activation of corticostriatal circuitry relieves chronic neuropathic pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Spatiotemporal changes in NSF expression of DRG neurons in a rat model of spinal nerve ligation.Journal of molecular neuroscience : MN · 2014Article
- The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Homers at the Interface between Reward and Pain.Frontiers in psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism(s) contributing to glutamate signaling in chronic pain remain unclear. Here we not only confirmed the key involvement of Homer proteins in neuropathic pain, but also distinguished between the functional roles for different Homer family members and isoforms. Chronic constriction injury (CCI) of the sciatic nerve induced long-lasting, time-dependent increases in the postsynaptic density expression of the constitutively expressed (CC) isoforms Homer1b/c and/or Homer2a/b in the spinal dorsal horn and supraspinal structures involved in nociception (prefrontal cortex, thalamus), that co-occurred with increases in their associated mGluRs, NR2 subunits of the NMDA receptor, and the activation of downstream kinases. Virus-mediated overexpression of Homer1c and Homer2b after spinal (intrathecal) virus injection exacerbated CCI-induced mechanical and cold hypersensitivity, however, Homer1 and Homer2 gene knockout (KO) mice displayed no changes in their neuropathic phenotype. In contrast, overexpression of the immediate early gene (IEG) Homer1a isoform reduced, while KO of Homer1a gene potentiated neuropathic pain hypersensitivity. Thus, nerve injury-induced increases in CC-Homers expression promote pain in pathological states, but IEG-Homer induction protects against both the development and maintenance of neuropathy. Additionally, exacerbated pain hypersensitivity in transgenic mice with reduced Homer binding to mGluR5 supports also an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. Such data indicate that nerve injury-induced changes in glutamate receptor/Homer signaling contribute in dynamic but distinct ways to neuropathic pain processing, which has relevance for the etiology of chronic pain symptoms and its treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.