ArticleCurrent biology : CB2013
The primate cerebellum selectively encodes unexpected self-motion.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Subthreshold violations of trajectory predictions are sensitive to TMS of cerebellum Crus I/II.Neuroimage. Reports · 2026Article
- Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula.Nature communications · 2026Article
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Effects of a Cerebellar Transcranial Direct-Current Stimulation-Based Preventive Exercise Program on Physical Function and Fall Reduction Efficacy in Community-Dwelling Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals.Nature neuroscience · 2026Article
- Predictive interception across speed profiles.Frontiers in neural circuits · 2026Article
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Validating sensory conflict theory and mitigating motion sickness in humans with galvanic vestibular stimulation.Communications engineering · 2025Article
- Reference Frames for Encoding of Translation and Tilt in the Caudal Cerebellar Vermis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dizziness and neck pain: a perspective on cervicogenic dizziness exploring pathophysiology, diagnostic challenges, and therapeutic implications.Frontiers in neurology · 2025Article
- Human proprioceptive gaze stabilization during passive body rotations underneath a fixed head.Scientific reports · 2024Article
- Cerebellar Purkinje cells in male macaques combine sensory and motor information to predict the sensory consequences of active self-motion.Nature communications · 2024Article
- Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch.Communications biology · 2024Article
- Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action.Brain structure & function · 2024Article
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural substrates of perception in the vestibular thalamus during natural self-motion: A review.Current research in neurobiology · 2023Review
- Highlights from the 31st Annual Meeting of the Society for the Neural Control of Movement.Journal of neurophysiology · 2023Article
- Cerebellar Representations of Errors and Internal Models.Cerebellum (London, England) · 2022Review
- Proprioceptive manipulations in orthograde posture modulate postural control in low back pain patients: a pilot study.Scientific reports · 2022Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe ability to distinguish sensory signals that register unexpected events (exafference) from those generated by voluntary actions (reafference) during self-motion is essential for accurate perception and behavior. The cerebellum is most commonly considered in relation to its contributions to the fine tuning of motor commands and sensorimotor calibration required for motor learning. During unexpected motion, however, the sensory prediction errors that drive motor learning potentially provide a neural basis for the computation underlying the distinction between reafference and exafference.
resultsRecording from monkeys during voluntary and applied self-motion, we demonstrate that individual cerebellar output neurons encode an explicit and selective representation of unexpected self-motion by means of an elegant computation that cancels the reafferent sensory effects of self-generated movements. During voluntary self-motion, the sensory responses of neurons that robustly encode unexpected movement are canceled. Neurons with vestibular and proprioceptive responses to applied head and body movements are unresponsive when the same motion is self-generated. When sensory reafference and exafference are experienced simultaneously, individual neurons provide a precise estimate of the detailed time course of exafference.
conclusionsThese results provide an explicit solution to the longstanding problem of understanding mechanisms by which the brain anticipates the sensory consequences of our voluntary actions. Specifically, by revealing a striking computation of a sensory prediction error signal that effectively distinguishes between the sensory consequences of self-generated and externally produced actions, our findings overturn the conventional thinking that the sensory errors coded by the cerebellum principally contribute to the fine tuning of motor activity required for motor learning.
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