ReviewMolecular and cellular endocrinology2013
Mitochondrial and skeletal muscle health with advancing age.
Review in Molecular and cellular endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effect of aerobic exercise on oxidative stress in patients with chronic kidney disease: a systematic review and meta-analysis with trial sequential analysis.Renal failure · 2023Pooled it
- A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis.Frontiers in physiology · 2021Pooled it
- The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Menopausal duration and relative skeletal muscle index predict metabolic inflexibility during walking in postmenopausal women with overweight/obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- The skeletal muscle proteomic determinants of neuromuscular function in young and older women following 8 weeks of resistance training.Experimental physiology · 2025Article
- Rating of Perceived Exertion: A Large Cross-Sectional Study Defining Intensity Levels for Individual Physical Activity Recommendations.Sports medicine - open · 2024Article
- Investigation of outcome measures and anomalous lower extremity in osteoarthritis patients with Jumpstart nutrition® supplementation.Caspian journal of internal medicine · 2024Review
- Prevalence of disability and associated functional limitations among older adults in Brazil.PLOS global public health · 2024Article
- Bio-Hacking Better Health-Leveraging Metabolic Biochemistry to Maximise Healthspan.Antioxidants (Basel, Switzerland) · 2023Article
- Biomonitoring the skeletal muscle metabolic dysfunction in knee osteoarthritis in older adults: Is Jumpstart Nutrition® Supplementation effective?Caspian journal of internal medicine · 2023Review
- 2-month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice.Aging cell · 2022Article
- Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice.BMC genomics · 2022Article
- Age, Education, and Stress Affect Ageing Males' Symptoms More than Lifestyle Does: The Wroclaw Male Study.International journal of environmental research and public health · 2022Article
- The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2021Review
- Article
- Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Moderate Exercise in Spontaneously Hypertensive Rats Is Unable to Activate the Expression of Genes Linked to Mitochondrial Dynamics and Biogenesis in Cardiomyocytes.Frontiers in endocrinology · 2020Article
- Role of Jumpstart NutritionMedical sciences (Basel, Switzerland) · 2019Article
- Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise.Antioxidants (Basel, Switzerland) · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
With increasing age there is a temporal relationship between the decline of mitochondrial and skeletal muscle volume, quality and function (i.e., health). Reduced mitochondrial mRNA expression, protein abundance, and protein synthesis rates appear to promote the decline of mitochondrial protein quality and function. Decreased mitochondrial function is suspected to impede energy demanding processes such as skeletal muscle protein turnover, which is critical for maintaining protein quality and thus skeletal muscle health with advancing age. The focus of this review was to discuss promising human physiological systems underpinning the decline of mitochondrial and skeletal muscle health with advancing age while highlighting therapeutic strategies such as aerobic exercise and caloric restriction for combating age-related functional impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.