ArticleJournal of the American College of Cardiology2013
Changes in cardiovascular risk factors by hysterectomy status with and without oophorectomy: Study of Women's Health Across the Nation.
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 91 citations in OpenAlex.
- Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan.Scientific reports · 2018Trial
- Emulating a target trial of surgical removal of uterine fibroids on atherosclerotic cardiovascular disease.Fertility and sterility · 2026Article
- Effect of hysterectomy on the risk of ovarian cancer: A South Korean national cohort study.PloS one · 2026Article
- Young Age at Hysterectomy and Elevated Hypertension Risk: A Combined Observational and Mendelian Randomization Study.Yonsei medical journal · 2025Observational
- Bilateral Oophorectomy Prevalence Among U.S. Women.Journal of women's health (2002) · 2024Article
- Hysterectomy With and Without Oophorectomy, Tubal Ligation, and Risk of Cardiovascular Disease in the Nurses' Health Study II.Journal of women's health (2002) · 2023Article
- Association between hysterectomy and hypertension among Indian middle-aged and older women: a cross-sectional study.BMJ open · 2023Article
- All-cause and cardiovascular mortality after hysterectomy and oophorectomy in a large cohort (HUNT2).Acta obstetricia et gynecologica Scandinavica · 2023Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Association between hysterectomy status and stroke risk and cause-specific and all-cause mortality: evidence from the 2005-2018 National Health and Nutrition Examination Survey.Frontiers in neurology · 2023Article
- The interplay between diabetes mellitus and menopause: clinical implications.Nature reviews. Endocrinology · 2022Review
- Cardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors.BMC medicine · 2022Article
- Traditional and Emerging Sex-Specific Risk Factors for Cardiovascular Disease in Women.Reviews in cardiovascular medicine · 2022Review
- Asian Best Practices for Care of Diabetes in Elderly (ABCDE).The review of diabetic studies : RDS · 2022Article
- Change in metabolic parameters and reproductive hormones from baseline to 6-month hormone therapy.Medicine · 2022Article
- 1Menstruation: a possible independent health promoter, aging and COVID-19.Caspian journal of internal medicine · 2022Review
- Lifestyle-related education and counseling resource utilization and cardiovascular biomarkers in midlife women with low physical activity.Preventive medicine reports · 2021Article
- Management of Cardiovascular Risk in Perimenopausal Women with Diabetes.Diabetes & metabolism journal · 2021Review
- Dual trajectories of physical activity and blood lipids in midlife women: The Study of Women's Health Across the Nation.Maturitas · 2021Article
- Changes in the glucose and insulin responses according to high-protein snacks for diabetic patients.Nutrition research and practice · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe aim of this study was to compare the changes in risk factors for cardiovascular disease (CVD) leading up to and after hysterectomy with or without bilateral oophorectomy with the changes observed up to and after natural menopause.
backgroundEvidence suggests that hysterectomy status with or without bilateral oophorectomy might increase risk for CVD, but most studies retrospectively assess menopausal status.
methodsStudy of Women's Health across the Nation enrolled 3,302 pre-menopausal women not using hormone therapy between 42 and 52 years of age and followed them annually for over 11 years for sociodemographic characteristics, menopausal status, surgeries, body mass index, medication use, lifestyle factors, lipids, blood pressure, insulin resistance, and hemostatic and inflammatory factors. By 2008, 1,769 women had reached natural menopause, 77 women had a hysterectomy with ovarian conservation, and 106 women had a hysterectomy with bilateral oophorectomy. Piece-wise hierarchical growth models compared these groups on annual changes in CVD risk factors before and after final menstrual period or surgery.
resultsMultivariable analyses showed that annual changes in CVD risk factors did not vary by group, with few exceptions, and the significant group differences that did emerge were not in the anticipated direction.
conclusionsHysterectomy with or without ovarian conservation is not a key determinant of CVD risk factor status either before or after elective surgery in midlife. These results should provide reassurance to women and their clinicians that hysterectomy in midlife is unlikely to accelerate the CVD risk of women.
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