ArticleInternational journal of cardiology2013
Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults: a community-based study.
Article in International journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Obstructive sleep apnea and the risk of sudden cardiac death: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Assessment of Atrial Fibrillation and Ventricular Arrhythmia Risk after Bariatric Surgery by P Wave/QT Interval Dispersion.Obesity surgery · 2018Trial
- Clinical features of retinopathy after cardiopulmonary resuscitation.BMC ophthalmology · 2023Article
- Interactions between Sleep Apnea and Coronary Artery Disease on the Incidence of Sudden Cardiac Arrest: A Multi-Center Case-Control Study.Yonsei medical journal · 2023Article
- The Impact of Obesity on Sudden Cardiac Death Risk.Current cardiology reports · 2022Review
- Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management.Arrhythmia & electrophysiology review · 2020Review
- Coronary Artery Disease and Atherosclerotic Risk Factors in a Population-Based Study of Sudden Death.Journal of general internal medicine · 2020Article
- The effect of MD1 on potassium and L-type calcium current of cardiomyocytes from high-fat diet mice.Channels (Austin, Tex.) · 2020Article
- Acute Responses of Cardiac Biomarkers to Intermittent and Continuous Exercise Are Related to Age Difference but Not I/D Polymorphism in the ACE Gene.Frontiers in physiology · 2020Article
- Lipoprotein(a) Elevation: A New Diagnostic Code with Relevance to Service Members and Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
- Ablation Approaches for Ventricular Fibrillation.Current treatment options in cardiovascular medicine · 2018Review
- Novel measure of autonomic remodeling associated with sudden cardiac arrest in diabetes.Heart rhythm · 2017Article
- Efficacy of acute care health care providers in cardiopulmonary resuscitation compressions in normal and obese adult simulation manikins.Proceedings (Baylor University. Medical Center) · 2017Article
- Warning Symptoms Are Associated With Survival From Sudden Cardiac Arrest.Annals of internal medicine · 2016Article
- Adiposity throughout adulthood and risk of sudden cardiac death in women.JACC. Clinical electrophysiology · 2015Article
- QRS fragmentation and sudden cardiac death in the obese and overweight.Journal of the American Heart Association · 2015Observational
- Obesity related risk of sudden cardiac death in the atherosclerosis risk in communities study.Heart (British Cardiac Society) · 2015Article
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8 authors.
Funding
Abstract
backgroundWhile sudden cardiac arrest (SCA) rates increase with age, middle-aged adults (35-59 years) may comprise a significant proportion of SCA cases in the community (30-40%). However, there is a lack of studies evaluating SCA risk factors specifically associated with this age-group of the population.
methodsUsing prospective multiple-source surveillance methodology we identified cases of SCA ≥35 years in the ongoing Oregon Sudden Unexpected Death Study (Portland, Oregon metropolitan area, population≈1,000,000). Out-of-hospital SCA cases, aged 35-59 years were compared to older SCA cases (≥60 years) in a comprehensive analysis of clinical profile of SCA.
resultsThe middle-aged (n=753) compared to older (n=1251) cases were more likely to be male, obese, have sleep apnea and seizure disorder (all p≤0.001); and were less likely to have a history of hypertension, diabetes mellitus, known coronary artery disease, congestive heart failure and syncope (all p<0.01). In multivariable analyses the middle-aged group had higher likelihood of male sex (O.R. 1.67, 95% C.I. 1.29-2.18), obesity (2.20, 1.52-3.19), sleep apnea (2.30, 1.44-3.68) and seizure disorder (2.69, 1.64-4.42); and lower rates of known coronary artery disease (0.57, 0.43-0.74) and congestive heart failure (0.35, 0.25-0.48).
conclusionsSCA in the middle-aged adult was distinguishable from older subjects by higher rates of obesity, sleep apnea and seizure disorder; and lower prevalence of traditional clinical risk markers. With the growing epidemic of obesity, these findings have implications for SCA burden; and suggest the need for a clinical and investigational focus on SCA prediction and prevention in the middle-aged adult, that is distinct from older adults.
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