ArticleTrends in endocrinology and metabolism: TEM2013
NHLH2: at the intersection of obesity and fertility.
Article in Trends in endocrinology and metabolism: TEM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Altered spontaneous brain activity is associated with cognitive impairment in patients with Kallmann syndrome.Reproductive biology and endocrinology : RB&E · 2026Article
- Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mapping the anatomical and transcriptional landscape of early human fetal ovary development.Scientific reports · 2025Article
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.PLoS biology · 2025Article
- Functional analysis of conservedbioRxiv : the preprint server for biology · 2024Article
- A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types.Science advances · 2024Article
- Identification and functional analysis of ovarian lncRNAs during different egg laying periods in Taihe Black-Bone Chickens.Frontiers in physiology · 2024Article
- In Silico Examination of Single Nucleotide Missense Mutations inInternational journal of molecular sciences · 2023Article
- Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.Human genetics · 2022Article
- Article
- Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles.Oncotarget · 2020Article
- A molecular conundrum involving hypothalamic responses to and roles of long non-coding RNAs following food deprivation.Molecular and cellular endocrinology · 2016Review
- Molecular regulation of hypothalamic development and physiological functions.Molecular neurobiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Nescient helix-loop-helix 2 (NHLH2/NSCL2) is a neuronal transcription factor originally thought to be involved in neuronal development and childhood neuroblastomas. Accumulating evidence has since identified roles for NHLH2 in adult phenotypes of obesity and fertility. We summarize these findings here and attempt to link genotype with phenotype in mouse models and humans. In particular, NHLH2 (Nhlh2 in mice) is one of only two genes that are genetically linked to physical activity levels. Nhlh2 also controls obesity and fertility, with strong sexual dimorphism for both phenotypes in Nhlh2 mutant animals. We propose that Nhlh2 might function as a molecular sensor in different adult hypothalamic neurons to regulate energy balance, leading to normal body weight and reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.