ArticleThe Journal of allergy and clinical immunology2013
Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: the Genes-environments and Admixture in Latino Asthmatics (GALA II) study.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- EVALUATING THE RELATIONSHIPS BETWEEN GENETIC ANCESTRY AND THE CLINICAL PHENOME.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Nature genetics · 2023Article
- Review
- Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm.Journal of personalized medicine · 2022Review
- PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses.Scientific reports · 2021Article
- Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma.Cell reports · 2020Article
- Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy.Respiratory research · 2020Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
- An ancestry-based approach for detecting interactions.Genetic epidemiology · 2018Article
- Allergic sensitization and objective measures of sleep in urban school-aged children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Respiratory Health in Migrant Populations: A Crisis Overlooked.Annals of the American Thoracic Society · 2017Review
- Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome.Genome biology · 2017Article
- Early-life ozone exposure associated with asthma without sensitization in Latino children.The Journal of allergy and clinical immunology · 2016Article
- Maternal age and asthma in Latino populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- A case-control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma.BMC pulmonary medicine · 2016Article
- Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos.American journal of respiratory and critical care medicine · 2016Article
- Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic.The Journal of allergy and clinical immunology · 2015Article
- The effect of parental social support and acculturation on childhood asthma control.The Journal of asthma : official journal of the Association for the Care of Asthma · 2015Article
- Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease.The Journal of allergy and clinical immunology · 2014Article
Corrections and comments
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Authors and funding
24 authors at 13 institutions in 3 countries.
Funding
Abstract
backgroundAtopy varies by ethnicity, even within Latino groups. This variation might be due to environmental, sociocultural, or genetic factors.
objectiveWe sought to examine risk factors for atopy within a nationwide study of US Latino children with and without asthma.
methodsAeroallergen skin test responses were analyzed in 1830 US Latino subjects. Key determinants of atopy included country/region of origin, generation in the United States, acculturation, genetic ancestry, and site to which subjects migrated. Serial multivariate zero-inflated negative binomial regressions stratified by asthma status examined the association of each key determinant variable with the number of positive skin test responses. In addition, the independent effect of each key variable was determined by including all key variables in the final models.
resultsIn baseline analyses African ancestry was associated with 3 times (95% CI, 1.62-5.57) as many positive skin test responses in asthmatic participants and 3.26 times (95% CI, 1.02-10.39) as many positive skin test responses in control participants. Generation and recruitment site were also associated with atopy in crude models. In final models adjusted for key variables, asthmatic patients of Puerto Rican (exp[β] [95% CI], 1.31 [1.02-1.69]) and mixed (exp[β] [95% CI], 1.27 [1.03-1.56]) ethnicity had a greater probability of positive skin test responses compared with Mexican asthmatic patients. Ancestry associations were abrogated by recruitment site but not region of origin.
conclusionsPuerto Rican ethnicity and mixed origin were associated with degree of atopy within US Latino children with asthma. African ancestry was not associated with degree of atopy after adjusting for recruitment site. Local environment variation, represented by site, was associated with degree of sensitization.
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